{{Genotype
|rsid=1050828
|allele1=A
|allele2=A
|magnitude=4
|repute=Bad
|summary=G6PD deficiency
}}
The A allele is associated with a reduction in [[glucose-6-phosphate dehydrogenase]] (G6PD) and is a diagnostic SNP of the type A- G6PD deficiency genotype.  Type A- is predominantly found in individuals with African ancestry.  The [[rs1050828]] A allele is also associated with malarial resistance.  Because rs1050828 is located on the x chromosome, males are either hemizygous for the A or G allele ([[rs1050828(G;G)]]).