{{Genotype
|rsid=17580
|allele1=A
|allele2=T
|magnitude=1
|repute=Bad
|summary=carrier of a variant in Alpha-1 Antitrypsin Deficiency
}}
This variant represents the PiS variant in alpha-1-antitrypsin deficiency where a homozygous individual has 60% enzymatic activity. This variant alone is unlikely to much effect, but 3-4% of heterozygotes are compound heterozygous with the more severe PiZ variant [[rs28931568(C;C)]], which is associated with an increased risk of [[emphysema]] and [[COPD]].