{{Genotype
|rsid=17580
|allele1=T
|allele2=T
|magnitude=1
|repute=Bad
|summary=a slightly reduced functionality form of Alpha-1 Antitrypsin Deficiency
}}
This variant represents the PiS variant in alpha-1-antitrypsin deficiency with 60% enzymatic activity.  No direct correlation with liver disease according to [http://www.med.upenn.edu/gastro/documents/AJGalpha1antitrypsindeficiency2008.pdf Liver Disease in Alpha 1-Antitrypsin Deﬁciency: A Review] and no increased risk of emphysema according to 
http://omim.org/entry/107400#0013