{{Genotype
|rsid=17612858
|allele1=T
|allele2=T
|magnitude=3
|repute=Bad
|summary=highest risk of Podoconiosis
}}
The presence of the minor allele (T) of this SNP was associated with an increased risk of susceptibility to podoconiosis substantially (odds ratio, 2.44 in the allelic model and 2.19 in the additive model). This is a neglected tropical disease which causes elephantitis when exposed to volcanic soil. {{PMID|22455414}}

An estimated one-fifth of Ethiopians carry the genetic variants that result in the debilitating disease. [http://www.genome.gov/27558535 http://www.genome.gov/27558535]