{{Genotype
|rsid=1800497
|allele1=T
|allele2=T
|magnitude=4
|repute=Bad
|summary=A1/A1: Bad at avoidance of errors. 0.25x lower OCD; 0.56x lower Tardive Diskinesia; higher ADHD; 1.4x Alcohol Dependence; lower Postoperative Nausea; Increased obesity; less pleasure response; Bupropion ineffective; 2.4x risk for adenoma recurrence.
}}
The DRD2 TaqIA A1/A1 version causes less dopamine receptors. Doesn't learn from mistakes well. Men have 0.25x reduced risk of Obsessive Compulsive Disorder but higher risk of ADHD. Women have lower Persistence. 0.56x reduced risk of Tardive Diskinesia when taking dopamine receptor antagonists. Slightly increased risk of alcoholism and smoking addiction. Slower recovery from traumatic brain injury. Lower risk of postoperative nausea within 6 hours of surgery. Bupropion (Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, Zyban, Voxra) doesn't help to quit smoking{{PMID|18058343}}. Increased obesity due to decreased pleasure response to food. 2.4x increased risk for [[adenoma]] recurrence.

Extrapyramidal adverse effects are associated with increased drug occupancy of the dopamine 2 receptors [[DRD2]].  The A1 allele of the [[DRD2/ANKK1]], [[rs1800497]], is associated with decreased striatal [[DRD2]] density.  Results strongly suggested that A1+ variants of the [[DRD2/ANKK1]] Taq1A allele do confer an associated risk for [[akathisia]] in patients who were treated with second-generation antipsychotics [[SGAs]], and these variants may explain inconsistencies found across prior studies, when comparing FGAs and SGAs.  {{PMID|23118020}}

Single marker analysis the [[TaqIA]] [[rs1800497]] and [[TaqIB]] [[rs1079597]] variants were associated with heroin dependence.

DRD2/ANKK1 Taq IA polymorphism is not associated with early infant temperament.  There were no differences in the temperament style distribution between the T-carrier and non-T carrier groups. There were also no statistically significant differences between the two groups in the score of the nine temperament dimensions. {{PMID|20199723}}


{{PMID|23118020}} DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia.

{{PMID|23840506}} Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence.

{{PMID|20199723}} [DRD2/ANKK1 Taq IA polymorphism and early infant temperament].