{{Genotype
| rsid = 1800795
| allele1 = G
| allele2 = G
|summary=more IL6; certain risks, see details
}}


[[rs1800795]] is a SNP in the promoter of the interleukin-6 [[IL6]] gene, affecting the levels made of this important cytokine. In the literature, it is almost universally referred to as the IL6 "-174" polymorphism. It tends to be quite polymorphic in Caucasians, but Asian and African populations are almost monomorphic (for the (G) allele).


The [[rs1800795]](G) allele, generally associated with higher levels of IL6, has been associated with increased risk in the following studies:

* The [[rs1800795]](G) allele was significantly associated with [[type-2 diabetes]] (odds ratio 1.51, CI: 1.11-2.07, p=0.0096) in a study of 700 elderly Caucasians.[PMID 15472205]

* Following a kidney transplant, patients with [[rs1800795]](G;G) genotypes have a higher risk of new-onset diabetes and higher C-reactive protein levels) compared to the (C;C) genotype. Since this was more pronounced in overweight patients, the authors suggest that diabetes-inducing drug administration should be limited in overweight patients who are [[rs1800795]](G;G) following renal transplantation.[PMID 16837641]

* The development of bronchiolitis obliterans syndrome (BOS) after lung transplantation is more likely and happens earlier for [[rs1800795]](G) carriers.[PMID 12451269]

* Among HIV+ men, the lifetime risk of developing Kaposi sarcoma is higher for [[rs1800795]](G;G) homozygotes compared to (C;C) homozygotes.[PMID 11001912]

* Patients with [[Hodgkin's lymphoma]] who are [[rs1800795]](G;G) were less likely to be successfully treated, with odds ratios for failure of 1.75 (CI: 1.04-2.92, p=0.03).[PMID 17496310]

* A study of 139 elderly males with acute coronary syndrome (ACS) indicated that [[rs1800795]](G;G) genotypes were at 3.89 fold (CI: 1.71-8.86, p=0.001) higher risk of dying within one year of their ACS event than (C;G) or (C;C) genotypes.[PMID 16098388]

* Although the odds of having a stroke weren't different, among patients (in this case, under 60 years of age) who did have a [[stroke]] those with a [[rs1800795]](G;G) genotype had more severe disability after 1 week (odds ratio 3.2, CI: 1.5-6.6, p=0.002).[PMID 14512079]

* Among Chinese patients with [[hypertension]], the [[rs1800795]](G) allele is more common, and (G;G) genotypes had significantly higher plasma PAI-1 activity than (C;C) genotypes.[PMID 15831362]

* In 168 Brazilian patients, [[rs1800795]](G) allele frequency was higher in gastric cancer than in patients with chronic gastritis. [PMID 17560462]

* Although the odds of having [[Crohn's disease]] aren't affected, among 153 children with it, those with the [[rs1800795]](G;G) genotype were more growth-retarded at diagnosis than (C;G) or (C;C) genotypes. (G;G) patients also had higher circulating levels of C-reactive protein (CRP).[PMID 16150725] 

* [[rs1800795]](G) carriers don't increase their high-density lipoprotein (HDL) levels after 24 weeks of aerobic exercise as much as [[rs1800795]](C) carriers.[PMID 15904871]

* The [[rs1800795]](G;G) genotype was more frequent in Australian infants with [[sudden infant death syndrome]] (58%) than in control subjects (38%, p=0.02).[PMID 17055359] This was not seen in a Norwegian population.[PMID 17509454]

* Women with [[endometriosis]] who are [[rs1800795]](G) carriers appear to be more likely to develop chocolate cysts, and (G) allele carriers may be at slightly higher risk of developing [[endometriosis]].[PMID 12517591]

* The [[rs1800795]](G) allele is more frequent in women with hyperandrogenism than in controls.[PMID 11889177]