{{Genotype
|allele1=A
|allele2=A
|rsid=2231142
|magnitude=3.5
|repute=Bad
|summary=causes gout
}}
At least 10% of all [[gout]] cases in whites are attributable to this causal variant. {{PMID|19506252}}

This variation influences uric acid concentrations and causes 53% reduced urate transport rates compared to wild-type. 

Reduced transport of chemotherapeutic agents by this mutation {{PMID|18370855}}. 

Other reported effects include 4x higher risk of diarrhea when taking [[gefitinib]] and 2x effectiveness of  [[rosuvastatin]].

What is the significance of this sentence in {{PMID|19506252}}?
<blockquote>Interestingly, [[rs2231142]] is located in the nucleotide-binding domain of ABCG2 right next to the corresponding amino acid F508 ([[rs113993960]]) in the nucleotide-binding domain of CFTR, a residue commonly mutated in patients with cystic fibrosis.</blockquote>