{{Rsnum
|rsid=1000113
|Chromosome=5
|position=150860514
|Orientation=plus
|GMAF=0.2121
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 91.2 | 8.8 | 0.0
| HCB | 38.7 | 48.2 | 13.1
| JPT | 44.2 | 40.7 | 15.0
| YRI | 51.7 | 45.6 | 2.7
| ASW | 57.9 | 38.6 | 3.5
| CHB | 38.7 | 48.2 | 13.1
| CHD | 29.4 | 53.2 | 17.4
| GIH | 88.1 | 10.9 | 1.0
| LWK | 67.3 | 31.8 | 0.9
| MEX | 69.0 | 25.9 | 5.2
| MKK | 62.8 | 32.1 | 5.1
| TSI | 71.6 | 27.5 | 1.0
| HapMapRevision=28
}}[[rs1000113]] has been reported in a large study to be associated with [[Crohn's disease]].

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.54 (CI 1.31-1.82), and for homozygotes, 1.92 (CI 0.92-4.00). {{PMID|17554300|OA=1
}}

{{ neighbor
| rsid = 4958847
| distance = 489
}}

{{GWAS Summary
|SNP=rs1000113
|PubMedID=17554300
|Condition=Crohn's disease
|Gene=IRGM
|Risk Allele=T
|pValue=3.00E-007
|OR=1.54
|95CI=1.31-1.82
|OA=1
}}

{{PharmGKB
|RSID=rs1000113
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,748 cases, 2,938 controls; Replication Sample Size: (see Parkes 2007); Risk Allele: rs1000113-T). This variant is associated with crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356635
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=19098858
|Title=Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease.
}}

{{PMID Auto
|PMID=20106866
|Title=Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1000113
|overall_frequency_n=27
|overall_frequency_d=128
|overall_frequency=0.210938
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}