{{Rsnum
|rsid=10010131
|Gene=WFS1
|Chromosome=4
|position=6291188
|Orientation=plus
|GMAF=0.2677
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=WFS1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.1 | 50.4 | 42.5
| HCB | 0.0 | 7.3 | 92.7
| JPT | 0.0 | 5.4 | 94.6
| YRI | 8.9 | 41.8 | 49.3
| ASW | 12.5 | 41.1 | 46.4
| CHB | 0.0 | 7.3 | 92.7
| CHD | 0.0 | 12.8 | 87.2
| GIH | 6.9 | 51.5 | 41.6
| LWK | 0.0 | 0.0 | 0.0
| MEX | 5.4 | 41.1 | 53.6
| MKK | 10.0 | 41.3 | 48.7
| TSI | 15.8 | 41.6 | 42.6
| HapMapRevision=28
}}

{{omim
|desc=DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
|id=125853
|rsnum=10010131
}}

{{omim
|desc=WFS1 GENE; WFS1
|id=606201
|rsnum=0021
|variant=10010131
}}

{{PharmGKB
|RSID=rs10010131
|Name_s=
|Gene_s=WFS1
|Feature=
|Evidence=PubMed ID:17603484
|Annotation=rs10010131 was found to be associated with Type 2 Diabetes risk in a case-control study of UK populations; the association was replicated in an Ashkenazi population.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162356066
}}
{{PMID Auto
|PMID=20028947
|Title=Detailed investigation of the role of common and low frequency WFS1 variants in type 2 diabetes risk
|OA=1
}}

{{PMID Auto
|PMID=20361036
|Title=Gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population
|OA=1
}}
{{PMID Auto
|PMID=20802253
|Title=Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
|OA=1
}}

{{PharmGKB
|RSID=rs10010131
|Name_s=
|Gene_s=WFS1
|Feature=
|Evidence=PubMed ID:18853134
|Annotation=In a large study of 16,143 non-diabetic individuals this SNP in the WFS1 gene predicted the development of at least two components of the metabolic syndrome.
|Drugs=
|Drug Classes=
|Diseases=Metabolic Diseases; Metabolic Syndrome X
|Curation Level=Curated
|PharmGKB Accession ID=PA162355883
}}

{{omim
|id=606201
|rsnum=0021
|variant=10010131
}}

{{omim
|id=606201
|rsnum=10010131
|variant=0021
}}

{{PMID Auto
|PMID=22513821
|Title=The association of genetic variants of type 2 diabetes with kidney function
|OA=1
}}

{{PMID|18040659|OA=1
}} Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.

{{PMID|18060660|OA=1
}} Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

{{PMID|18426861|OA=1
}} Association analysis of type 2 diabetes Loci in type 1 diabetes.

{{PMID|18591388|OA=1
}} Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

{{PMID|18694974|OA=1
}} Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.

{{PMID|18782870|OA=1
}} Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.

{{PMID|18984664}} Common type 2 diabetes risk gene variants associate with gestational diabetes.

{{PMID|19056611|OA=1
}} Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

{{PMID|19096518|OA=1
}} Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

{{PMID|19207020|OA=1
}} Meta-analysis in genome-wide association studies.

{{PMID|19279076|OA=1
}} Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.

{{PMID|19324937|OA=1
}} Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

{{PMID|19330314}} A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.

{{PMID|19341491|OA=1
}} Genome-based prediction of common diseases: methodological considerations for future research.

{{PMID|19455305|OA=1
}} No association of multiple type 2 diabetes loci with type 1 diabetes.

{{PMID|19460916|OA=1
}} Genetic architecture of type 2 diabetes: recent progress and clinical implications.

{{PMID|19502414|OA=1
}} Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

{{PMID|19526209|OA=1
}} Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

{{PMID|19602701|OA=1
}} Underlying genetic models of inheritance in established type 2 diabetes associations.

{{PMID|19862325|OA=1
}} PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

{{PMID|20017978|OA=1
}} Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

{{PMID|20018041|OA=1
}} The effect of multiple genetic variants in predicting the risk of type 2 diabetes.

{{PMID|20043853|OA=1
}} Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

{{PMID|20144327|OA=1
}} A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

{{PMID|20509872|OA=1
}} Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

{{PMID|20712903|OA=1
}} Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

{{PMID|21127832}} Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective study.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{PMID|22461567|OA=1
}} Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10010131
|overall_frequency_n=6746
|overall_frequency_d=10758
|overall_frequency=0.627068
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=3
|n_articles_annotated=3
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23257691
|Title=Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis
}}

{{PMID Auto
|PMID=22996131
|Title=Monogenic models: what have the single gene disorders taught us?
|OA=1
}}

{{PMID Auto
|PMID=23298195
|Title=Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}