{{Rsnum
|rsid=10033464
|Chromosome=4
|position=110799605
|Orientation=plus
|GMAF=0.1635
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 82.3 | 15.9 | 1.8
| HCB | 61.5 | 33.3 | 5.2
| JPT | 51.3 | 41.6 | 7.1
| YRI | 58.0 | 35.7 | 6.3
| ASW | 70.2 | 26.3 | 3.5
| CHB | 61.5 | 33.3 | 5.2
| CHD | 67.0 | 29.2 | 3.8
| GIH | 65.0 | 33.0 | 2.0
| LWK | 65.1 | 30.3 | 4.6
| MEX | 70.2 | 26.3 | 3.5
| MKK | 81.9 | 17.4 | 0.6
| TSI | 81.8 | 18.2 | 0.0
| HapMapRevision=28
}}Two SNPs from chromosome 4q25, [[rs2200733]] and [[rs10033464]], were found to be associated with [[atrial fibrillation]] in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.{{PMID|17603472}}

{{PMID|18991354}} In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, [[rs10033464]] was associated with cardioembolic [[stroke]] (CES) (odds ratio 1.27, p = 6.1 x 10e-4). 

{{PMID|19141561|OA=1
}} [[rs2200733]] and [[rs10033464]] are strongly associated with AF in four cohorts of European descent. 

{{GWAS Summary
|SNP=rs10033464
|PubMedID=17603472
|Condition=Atrial fibrillation/atrial flutter
|Gene=PITX2,ENPEP
|Risk Allele=T
|pValue=7.00E-011
|OR=1.39
|95CI=1.26-1.53
}}

{{omim
|desc=ATRIAL FIBRILLATION, FAMILIAL, 5; ATFB5
|id=611494
|rsnum=10033464
}}

{{PharmGKB
|RSID=rs10033464
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17603472; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Variants conferring risk of atrial fibrillation on chromosome 4q25 (Initial Sample Size: 550 cases, 4,476 controls; Replication Sample Size: 3,363 cases, 17,616 controls; Risk Allele: rs10033464-T). This variant is associated with atrial fibrillation and atrial flutter.
|Drugs=
|Drug Classes=
|Diseases=Atrial Fibrillation; Atrial Flutter
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356664
}}

{{PMID Auto
|PMID=21414601
|Title=Usefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long-Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting
|OA=1
}}

{{PMID Auto
|PMID=21760908
|Title=Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population
|OA=1
}}

{{PMID|20031626|OA=1
}} Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.

{{PMID|20170812}} Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.

{{PMID|20173747|OA=1
}} Common variants in KCNN3 are associated with lone atrial fibrillation.

{{PMID|20606429}} Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.

{{PMID|20671249}} The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology.

{{PMID|20676228|OA=1
}} Lone AF - etiologic factors and genetic insights into pathophysiolgy.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10033464
|overall_frequency_n=105
|overall_frequency_d=128
|overall_frequency=0.820312
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=89
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22726630
|Title=Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.
|OA=1
}}

{{PMID Auto
|PMID=22818067
|Title=Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.
|OA=1
}}

{{PMID Auto
|PMID=23178686
|Title=Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation.
|OA=1
}}

{{PMID Auto
|PMID=23428961
|Title=Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion.
|OA=1
}}

{{PMID Auto
|PMID=24065534
|Title=Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}