{{Rsnum
|rsid=10042486
|Chromosome=5
|position=63965502
|Orientation=plus
|GMAF=0.3861
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 25.2 | 48.6 | 26.1
| HCB | 4.4 | 32.6 | 63.0
| JPT | 0.9 | 31.9 | 67.3
| YRI | 4.1 | 36.6 | 59.3
| ASW | 8.8 | 42.1 | 49.1
| CHB | 4.4 | 32.6 | 63.0
| CHD | 2.8 | 32.1 | 65.1
| GIH | 15.0 | 52.0 | 33.0
| LWK | 4.6 | 38.5 | 56.9
| MEX | 20.7 | 63.8 | 15.5
| MKK | 7.7 | 36.5 | 55.8
| TSI | 31.4 | 56.9 | 11.8
| HapMapRevision=28
}}{{PMID Auto
|PMID=19326813
|Title=A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers
}}

{{PharmGKB
|RSID=rs10042486
|Name_s=
|Gene_s=HTR1A
|Feature=
|Evidence=PubMed ID:18484082
|Annotation=A study, investigating the response of SSRI in 137 Japanese major depression subjects, observed a significant association of better response to antidepressant in rs10042486 (P < 0.0001), rs6295 (P < 0.0001) and rs1364043 (P = 0.018) genotype carriers (minor allele homozygotes), independently from clinical variables. The rs6295 variant has been found to affect the expression and function of HTR1A. rs6295 is in strong linkage disequilibrium with other polymorphisms of HTR1A.
|Drugs=fluvoxamine; paroxetine
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA161749005
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=22064163
|Title=Sertraline (Zoloft) response in major depressive disorder is not associated with three 5-HT1A receptor gene polymorphisms (rs6295, rs10042486, or rs1364043) in Chinese-Han patients.
}}

{{PMID Auto
|PMID=22120873
|Title=Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10042486
|overall_frequency_n=81
|overall_frequency_d=128
|overall_frequency=0.632812
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=74
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23308375
|Title=Association between HTR1A gene polymorphisms and attention deficit hyperactivity disorder in Korean children.
}}

{{PMID Auto
|PMID=23495896
|Title=Investigation of epistasis between DAOA and 5HTR1A variants on clinical outcomes in patients with schizophrenia.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}