{{Rsnum
|rsid=10045431
|Chromosome=5
|position=159387525
|Orientation=plus
|GMAF=0.1758
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 5.3 | 38.1 | 56.6
| HCB | 1.5 | 22.6 | 75.9
| JPT | 0.0 | 12.4 | 87.6
| YRI | 1.4 | 10.2 | 88.4
| ASW | 0.0 | 24.6 | 75.4
| CHB | 1.5 | 22.6 | 75.9
| CHD | 0.0 | 22.0 | 78.0
| GIH | 6.9 | 20.8 | 72.3
| LWK | 0.0 | 9.1 | 90.9
| MEX | 3.4 | 29.3 | 67.2
| MKK | 0.6 | 19.4 | 80.0
| TSI | 5.9 | 54.9 | 39.2
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs10045431
|PubMedID=18587394
|Condition=Crohn's disease
|Gene=IL12B
|Risk Allele=C
|pValue=4.00E-013
|OR=1.11
|95CI=
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 19; IBD19
|id=612278
|rsnum=10045431
}}

{{omim
|desc=PSORIASIS SUSCEPTIBILITY 11; PSORS11
|id=612599
|rsnum=10045431
}}

{{PharmGKB
|RSID=rs10045431
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18587394; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease (Initial Sample Size: 3,230 cases 4,829 controls; Replication Sample Size: 2,325 cases 1,809 controls 1,339 affected trios; Risk Allele: rs10045431-C).
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356802
}}

{{PMID Auto GWAS
|PMID=20570966
|Trait=Crohn's disease
|Title=Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease
|RiskAllele=
|Pval=7E-8
|OR=1.45
|ORtxt=[1.27-1.64]
|OA=1
}}

DeCode reports that [[rs10045431]] affects susceptibility to [[Crohn's disease]]. {{PMID|18587394|OA=1
}}

{{PMID|17587057}} Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

{{PMID|18438406|OA=1
}} Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

{{PMID|19068216|OA=1
}} Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

{{PMID|19468064|OA=1
}} Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

{{PMID|19557189|OA=1
}} Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

{{PMID|21304977|OA=1
}} An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10045431
|overall_frequency_n=110
|overall_frequency_d=128
|overall_frequency=0.859375
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=95
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22194214
|Title=Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}