{{Rsnum
|rsid=10046
|Gene=CYP19A1
|Chromosome=15
|position=51210789
|Orientation=minus
|GMAF=0.41
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CYP19A1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 47.8 | 32.7
| HCB | 21.2 | 52.6 | 26.3
| JPT | 29.1 | 47.3 | 23.6
| YRI | 68.0 | 30.6 | 1.4
| ASW | 66.7 | 26.3 | 7.0
| CHB | 21.2 | 52.6 | 26.3
| CHD | 22.0 | 49.5 | 28.4
| GIH | 43.6 | 48.5 | 7.9
| LWK | 55.5 | 40.9 | 3.6
| MEX | 36.8 | 50.9 | 12.3
| MKK | 33.3 | 50.6 | 16.0
| TSI | 30.7 | 42.6 | 26.7
| HapMapRevision=28
}}{{PMID|18274619|OA=1
}} [[rs10046]] is a SNP potentially linked in a gender-specific manner to [[hypertension]]

{{PMID|19152063}} [[rs10046]](C;C) associated with miscarriages (P = 0.017)

{{PMID Auto
|PMID=19366906
|Title=BRCA1 Breast Cancer Risk Is Modified by CYP19 Polymorphisms in Ashkenazi Jews
}}

{{PMID Auto
|PMID=19573564
|Title=Effect of the cytochrome P450 19 (aromatase) gene polymorphism on personality traits in healthy subjects
}}

{{PMID Auto
|PMID=19921206
|Title=Association of polymorphisms in CYP19A1 and CYP3A4 genes with lower urinary tract symptoms, prostate volume, uroflow and PSA in a population-based sample
|OA=1
}}

{{PMID Auto
|PMID=20144226
|Title=A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole
|OA=1
}}

{{PMID Auto
|PMID=19952760
|Title=Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men
}}
{{PMID Auto
|PMID=20432167
|Title=Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
}}
{{PMID Auto
|PMID=20586553
|Title=Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis
}}
{{PMID Auto
|PMID=20797716
|Title=Epistasis between CYP19A1 and ESR1 polymorphisms is associated with premature ovarian failure
}}

{{PMID Auto
|PMID=21790896
|Title=Genetic and environmental predictors, endogenous hormones and growth factors and risk of estrogen receptor-positive breast cancer in Japanese women
}}

{{PMID Auto
|PMID=22511967
|Title=Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India
|OA=1
}}

{{PMID|15199113}} Polymorphisms associated with circulating sex hormone levels in postmenopausal women.

{{PMID|16412218|OA=1
}} Multilocus analysis of SNP and metabolic data within a given pathway.

{{PMID|17615053|OA=1
}} Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.

{{PMID|17893373}} Sex and body mass index specific regulation of blood pressure by CYP19A1 gene variants.

{{PMID|17903296|OA=1
}} Genome-wide association with bone mass and geometry in the Framingham Heart Study.

{{PMID|18049890}} Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients.

{{PMID|18086758|OA=1
}} Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.

{{PMID|18159088}} Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome.

{{PMID|18199708|OA=1
}} Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study.

{{PMID|18245543}} A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.

{{PMID|18603647|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

{{PMID|18622258|OA=1
}} Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women.

{{PMID|18628428|OA=1
}} Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

{{PMID|18629629}} Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.

{{PMID|18636124|OA=1
}} Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

{{PMID|18941913|OA=1
}} Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.

{{PMID|19015200|OA=1
}} Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.

{{PMID|19064562|OA=1
}} Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China.

{{PMID|19630952|OA=1
}} Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.

{{PMID|19794821|OA=1
}} Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women.

{{PMID|21269619}} Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure.

{{PMID Auto
|PMID=23342035
|Title=Associations between Aromatase CYP19 rs10046 Polymorphism and Breast Cancer Risk: From a Case-Control to a Meta-Analysis of 20,098 Subjects
|OA=1
}}

{{PMID Auto
|PMID=23129173
|Title=Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole
|OA=1
}}

{{PMID Auto
|PMID=23700878
|Title=Research on aromatase gene (CYP19A1) polymorphisms as a predictor of endocrine therapy effectiveness in breast cancer
}}

{{PMID Auto
|PMID=24402127
|Title=Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer
|OA=1
}}

{{PMID Auto
|PMID=22633539
|Title=Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.
|OA=1
}}

{{PMID Auto
|PMID=23669293
|Title=CYP19A1 gene polymorphisms and risk of lung cancer.
}}

{{PMID Auto
|PMID=23809139
|Title=Polymorphic variants of CYP17 and CYP19A and risk of infertility in endometriosis.
}}

{{PMID Auto
|PMID=24968701
|Title=CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women
}}

{{PMID Auto
|PMID=24274352
|Title=Green tea consumption and breast cancer risk in Japanese women: a case-control study
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}