{{Rsnum
|rsid=10050860
|Gene=ERAP1
|Chromosome=5
|position=96786506
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1322
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ERAP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 55.8 | 37.2 | 7.1
| HCB | 86.1 | 13.9 | 0.0
| JPT | 85.8 | 14.2 | 0.0
| YRI | 88.4 | 10.9 | 0.7
| ASW | 82.5 | 17.5 | 0.0
| CHB | 86.1 | 13.9 | 0.0
| CHD | 89.9 | 10.1 | 0.0
| GIH | 87.1 | 12.9 | 0.0
| LWK | 93.6 | 6.4 | 0.0
| MEX | 86.2 | 13.8 | 0.0
| MKK | 87.2 | 12.2 | 0.6
| TSI | 64.7 | 33.3 | 2.0
| HapMapRevision=28
}}
[[rs10050860]] is one of several SNPs in the [[ERAP1]] gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with [[ankylosing spondylitis]]. The odds ratio is 0.71 (p=7.7x10e-9).[PMID 17952073, PMID 18037607]

Note that the text description (but not the result) at 23andMe is wrong. It is the uncommon T allele that gives protection.

{{PMID Auto
|PMID=19404951
|Title=Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis
}}

{{PMID Auto
|PMID=20032103
|Title=Association of ARTS1 Gene Polymorphisms with Ankylosing Spondylitis in the Hungarian Population: The rs27044 Variant Is Associated with HLA-B*2705 Subtype in Hungarian Patients with Ankylosing Spondylitis
}}

{{PMID Auto
|PMID=19414429
|Title=ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans
}}

{{PMID Auto
|PMID=21229357
|Title=The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls
}}

{{PMID|19433412}} Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.

{{PMID|19692350|OA=1
}} Investigating the genetic association between ERAP1 and ankylosing spondylitis.

{{PMID|20595269}} Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.

{{PMID|21865284}} ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.

{{PMID|21877190}} Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.

{{PMID Auto
|PMID=22896742
|Title=Investigating the genetic association between ERAP1 and spondyloarthritis
}}

{{GET Evidence
|gene=ERAP1
|aa_change=Asp575Asn
|aa_change_short=D575N
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10050860
|overall_frequency_n=1885
|overall_frequency_d=10758
|overall_frequency=0.175218
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.001
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}