{{Rsnum
|rsid=1006737
|Gene=CACNA1C
|Chromosome=12
|position=2236129
|Orientation=plus
|GMAF=0.3049
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CACNA1C
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 13.4 | 42.9 | 43.8
| HCB | 1.5 | 10.2 | 88.3
| JPT | 0.0 | 12.5 | 87.5
| YRI | 37.9 | 43.4 | 18.6
| ASW | 26.3 | 52.6 | 21.1
| CHB | 1.5 | 10.2 | 88.3
| CHD | 0.0 | 11.0 | 89.0
| GIH | 5.0 | 44.0 | 51.0
| LWK | 30.9 | 51.8 | 17.3
| MEX | 8.8 | 42.1 | 49.1
| MKK | 8.3 | 52.6 | 39.1
| TSI | 5.9 | 36.6 | 57.4
| HapMapRevision=28
}}

[http://blog.23andme.com/2008/08/18/snpwatch-snps-in-ion-channel-genes-are-associated-with-type-2-diabetes-and-bipolar-disorder/ 23andMe blog] [[rs1006737]] or ([[rs2159100]]) Each T at this SNP increased the odds of [[bipolar disorder]] by 1.18 times compared to having two CC copies

{{PMID Auto GWAS
|PMID=18711365
|Trait=Bipolar disorder
|Title=Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in [[bipolar disorder]]
|RiskAllele=A
|Pval=7E-8
|OR=1.18
|ORtxt=[NR]
|OA=1
}}

{{omim
|desc=MAJOR AFFECTIVE DISORDER 1; MAFD1
|id=125480
|rsnum=1006737
}}

{{omim
|desc=MAJOR AFFECTIVE DISORDER 9; MAFD9
|id=612372
|rsnum=1006737
}}
{{PMID Auto
|PMID=19621016
|Title=The [[bipolar disorder]] risk allele at CACNA1C also confers risk of recurrent major depression and of [[schizophrenia]]
|OA=1
}}
{{PMID Auto
|PMID=19781653
|Title=Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals
}}

{{PharmGKB
|RSID=rs1006737
|Name_s=
|Gene_s=CACNA1C
|Feature=
|Evidence=PubMed ID:18711365
|Annotation=A genome-wide association analysis study in 4,387 cases and 6,209 controls identified a strong association of this variant in the CACNA1C gene with bipolar disorder.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162355589
}}

{{PMID Auto GWAS
|PMID=20351715
|Trait=Bipolar disorder and major depressive disorder (combined)
|Title=Meta-analysis of genome-wide association data of [[bipolar disorder]] and major depressive disorder
|RiskAllele=A
|Pval=3E-8
|OR=1.18
|ORtxt=[NR] (bipolar)
|OA=1
}}
{{PMID Auto
|PMID=20638048
|Title=Genetic variation in CACNA1C, a gene associated with [[bipolar disorder]], influences brainstem rather than gray matter volume in healthy individuals
}}
{{PMID Auto
|PMID=20636642
|Title=Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
}}
{{PMID Auto
|PMID=20679588
|Title=Brain function in carriers of a genome-wide supported [[bipolar disorder]] variant
}}
{{PMID Auto
|PMID=20819988
|Title=Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness
|OA=1
}}
{{PMID Auto
|PMID=21042317
|Title=Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
|OA=1
}}

{{PMID Auto
|PMID=21292451
|Title=Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with [[bipolar disorder]]
}}

{{PMID Auto
|PMID=21676128
|Title=The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
}}

{{PMID Auto
|PMID=22012475
|Title=The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder
|OA=1
}}

{{PMID Auto
|PMID=22085483
|Title=The association of genetic variation in CACNA1C with structure and function of a frontotemporal system
|OA=1
}}

{{PMID Auto
|PMID=19388002
|Title=Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder.
}}

{{PMID Auto
|PMID=19416921
|Title=Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.
|OA=1
}}

{{PMID Auto
|PMID=20098439
|Title=CACNA1C (rs1006737) is associated with schizophrenia.
}}

{{PMID Auto
|PMID=20226536
|Title=Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.
}}

{{PMID Auto
|PMID=21078228
|Title=Effects of a CACNA1C genotype on attention networks in healthy individuals.
}}

{{PMID Auto
|PMID=21395576
|Title=No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.
}}

{{PMID Auto
|PMID=21767209
|Title=ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.
}}

{{PMID Auto
|PMID=22665259
|Title=The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1006737
|overall_frequency_n=50
|overall_frequency_d=126
|overall_frequency=0.396825
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23404764
|Title=Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity
}}

{{PMID Auto
|PMID=23406546
|Title=The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder
}}

{{PMID Auto
|PMID=23437284
|Title=CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23453885
  |Trait=Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)
  |Title=Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
  |RiskAllele=
  |Pval=5E-9
  |OR=1.07
  |ORtxt=[1.05-1.10]
  |OA=1
}}

{{PMID Auto
|PMID=23979604
|Title=A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain
}}

{{PMID Auto
|PMID=24108394
|Title=Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder
}}

{{PMID Auto
|PMID=24262814
|Title=CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population
}}

{{PMID Auto
|PMID=24269271
|Title=The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: A diffusion tensor imaging study
}}

{{PMID Auto
|PMID=22005930
|Title=Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|OA=1
}}

{{PMID Auto
|PMID=22290120
|Title=The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).
|OA=1
}}

{{PMID Auto
|PMID=22914618
|Title=Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder.
}}

{{PMID Auto
|PMID=23070075
|Title=Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
}}

{{PMID Auto
|PMID=23437964
|Title=Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: a family-based association study.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24280982
  |Trait=Schizophrenia or bipolar disorder
  |Title=Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
  |RiskAllele=
  |Pval=6E-13
  |OR=NR
  |ORtxt=NR
  }}

{{PMID Auto
|PMID=25124521
|Title=Replication of previous genome-wide association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}