{{Rsnum
|rsid=10090154
|Chromosome=8
|position=127519892
|Orientation=plus
|GMAF=0.1295
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 89.1 | 10.9 | 0.0
| HCB | 86.4 | 9.1 | 4.5
| JPT | 75.6 | 19.5 | 4.9
| YRI | 70.7 | 24.1 | 5.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 86.4 | 9.1 | 4.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs10090154]] is a SNP in chromosome [[8q24]] "region 1", associated with increased risk for [[prostate cancer]]. The odds ratio for the (T) risk allele were 1.42 (CI: 1.07-1.87, p=0.014), and they were not significantly different between Caucasians and African-Americans in this study of ~500 patients.{{PMID|18231127|OA=1
}} 

In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 1) of advanced [[prostate cancer]].{{PMID|18231127|OA=1
}}

Note that a meta-analysis across 10+ studies, including over 15,000 [[prostate cancer]] cases, reported the risk for a different SNP ([[rs1447295]]) representing the same region, "region 1", of this chromosome.{{PMID|1823127}}

{{PMID Auto
|PMID=19857256
|Title=Association between an 8q24 locus and the risk of colorectal cancer in Japanese
|OA=1
}}

{{PMID Auto
|PMID=19866473
|Title=Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
|OA=1
}}

{{PMID Auto
|PMID=21051319
|Title=Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study
|OA=1
}}

{{omim
|id=611100
|rsnum=10090154
}}

{{PMID Auto
|PMID=22549899
|Title=Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans
|OA=1
}}

{{PMID Auto
|PMID=17618282
|Title=A common genetic risk factor for colorectal and prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18349290
|Title=Association of genetic variants at 8q24 with breast cancer risk.
}}

{{PMID Auto
|PMID=18360876
|Title=Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18483343
|Title=Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk.
}}

{{PMID Auto
|PMID=18577746
|Title=Multiple loci with different cancer specificities within the 8q24 gene desert.
|OA=1
}}

{{PMID Auto
|PMID=18704501
|Title=Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
|OA=1
}}

{{PMID Auto
|PMID=19155440
|Title=Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
|OA=1
}}

{{PMID Auto
|PMID=19520795
|Title=Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
|OA=1
}}

{{PMID Auto
|PMID=19680443
|Title=Functional enhancers at the gene-poor 8q24 cancer-linked locus.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20584312
|Title=8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=22099997
|Title=Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men.
}}

{{PMID Auto GWAS
  |PMID=22923026
  |Trait=Prostate cancer
  |Title=Evaluating genetic risk for prostate cancer among Japanese and Latinos.
  |RiskAllele=T
  |Pval=3E-6
  |OR=1.68
  |ORtxt=[1.35-2.09]
  |OA=1
}}

{{PMID Auto
|PMID=23935004
|Title=Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia
}}

{{PMID Auto
|PMID=23628314
|Title=A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}