{{Rsnum
|rsid=10096633
|Chromosome=8
|position=19973410
|Orientation=plus
|GMAF=0.2071
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 75.2 | 21.2 | 3.5
| HCB | 81.8 | 17.5 | 0.7
| JPT | 81.4 | 17.7 | 0.9
| YRI | 24.5 | 52.4 | 23.1
| ASW | 35.1 | 57.9 | 7.0
| CHB | 81.8 | 17.5 | 0.7
| CHD | 77.1 | 22.0 | 0.9
| GIH | 79.2 | 20.8 | 0.0
| LWK | 24.5 | 47.3 | 28.2
| MEX | 75.9 | 22.4 | 1.7
| MKK | 35.9 | 53.2 | 10.9
| TSI | 64.7 | 29.4 | 5.9
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060911
|Trait=Triglycerides
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=2E-18
|OR=0.17
|ORtxt=[NR] SD increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=19060910
|Trait=Other metabolic traits
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|RiskAllele=A
|Pval=5E-8
|OR=0.12
|ORtxt=[0.07-0.17] mmol/l decrease
|OA=1
}}

{{PharmGKB
|RSID=rs10096633
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 17,815 individuals; Replication Sample Size: NR); (Region: 8p21.3; Reported Gene(s): LPL; Risk Allele: rs10096633-G); (p-value= 0.000000000000000002).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740231
}}

{{omim
|desc=LIPOPROTEIN LIPASE; LPL
|id=609708
|rsnum=10096633
}}

{{PharmGKB
|RSID=rs10096633
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060910; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (Initial Sample Size: 4,763 individuals; Replication Sample Size: NR); (Region: 8p21.3; Reported Gene(s): LPL; Risk Allele: rs10096633-A); (p-value= 0.00000005).This variant is associated with Other metabolic traits.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740291
}}
{{PMID Auto
|PMID=21252145
|Title=Physical Activity Modifies the Effect of LPL, LIPC and CETP Polymorphisms on HDL-C Levels and the Risk of Myocardial Infarction in Caucasian Women
|OA=1
}}

{{PMID Auto
|PMID=18078817
|Title=Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.
|OA=1
}}

{{PMID Auto
|PMID=19148283
|Title=Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=21347282
|Title=Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10096633
|overall_frequency_n=32
|overall_frequency_d=128
|overall_frequency=0.25
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}