{{Rsnum
|rsid=1012053
|Gene=DGKH
|Chromosome=13
|position=42079301
|Orientation=plus
|GMAF=0.2548
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Bipolar I Disorder
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=DGKH
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 77.0 | 20.4 | 2.7
| HCB | 28.1 | 51.9 | 20.0
| JPT | 19.5 | 52.2 | 28.3
| YRI | 89.8 | 9.5 | 0.7
| ASW | 75.4 | 24.6 | 0.0
| CHB | 28.1 | 51.9 | 20.0
| CHD | 31.5 | 50.0 | 18.5
| GIH | 57.0 | 34.0 | 9.0
| LWK | 80.0 | 20.0 | 0.0
| MEX | 45.6 | 45.6 | 8.8
| MKK | 74.2 | 25.2 | 0.6
| TSI | 65.7 | 31.4 | 2.9
| HapMapRevision=28
}}
Bipolar disorder failed to replicate in {{doi|10.1371/journal.pone.0023473}}

{{GWAS Summary
|SNP=rs1012053
|PubMedID=17486107
|Condition=Bipolar disorder
|Gene=DGKH
|Risk Allele=A
|pValue=2.00E-008
|OR=1.59
|95CI=1.35-1.87
|OA=1
}}

{{PharmGKB
|RSID=rs1012053
|Name_s=
|Gene_s=MAPK6PS3, DGKH
|Feature=
|Evidence=PubMed ID:17486107; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder (Initial Sample Size: 461 cases, 563 controls; Replication Sample Size: 772 cases, 876 controls; Risk Allele: rs1012053-A).
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356620
}}

{{PMID Auto
|PMID=21771265
|Title=Genome wide association study on bipolar disorder in the Bulgarian population
}}

{{PMID Auto
|PMID=18421293
|Title=Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement.
|OA=1
}}

{{PMID Auto
|PMID=19416921
|Title=Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.
|OA=1
}}

{{PMID Auto
|PMID=19818381
|Title=Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
}}

{{PMID Auto
|PMID=22048461
|Title=Effect of variation in diacylglycerol kinase eta (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1012053
|overall_frequency_n=102
|overall_frequency_d=124
|overall_frequency=0.822581
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=87
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}