{{Rsnum
|rsid=1015362
|Chromosome=20
|position=34150806
|Orientation=plus
|GMAF=0.3806
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 5.3 | 42.5 | 52.2
| HCB | 2.9 | 19.7 | 77.4
| JPT | 9.7 | 34.5 | 55.8
| YRI | 71.4 | 26.5 | 2.0
| ASW | 68.4 | 28.1 | 3.5
| CHB | 2.9 | 19.7 | 77.4
| CHD | 8.3 | 25.7 | 66.1
| GIH | 2.0 | 20.8 | 77.2
| LWK | 60.0 | 32.7 | 7.3
| MEX | 10.3 | 48.3 | 41.4
| MKK | 19.2 | 62.2 | 18.6
| TSI | 8.8 | 46.1 | 45.1
| HapMapRevision=28
}}[[rs1015362]] is a SNP  near the [[ASIP]] (agouti signaling protein) gene on chromosome 20. 

This SNP is one of a tightly-linked pair that increases the likelihood of an individual being prone to [[sun sensitivity]], in other words, freckles and sunburn, based on a study of 6,000+ Caucasians (5,000+ Icelanders + 1,000+ Dutch). The odds ratios, presumably on a dominant basis, and at least in the largest population (Icelanders) for "freckles and burns vs. no freckles and tans" for the haplotype pair [[rs1015362]](G) - [[rs4911414]](T) is 3.91 (CI: 2.54-6.03) for males and 2.42 (CI: 1.52-3.86) for females, with an overall p=0.051.{{PMID|18488028}}

Based on a study by the same authors of 4,000+ [[skin cancer]] patients, this haplotype was seen to confer significant increased risk for cutaneous [[malignant melanoma]] (odds ratio 1.45, p = 1.2 x 10<sup>-9</sup>) as well as basal cell carcinoma (odds ratio 1.33, p = 1.2 x 10<sup>-6</sup>).{{PMID|18488027}}

{{GWAS Summary
|SNP=rs1015362,rs4911414
|PubMedID=18488028
|Condition=Skin sensitivity to sun
|Gene=ASIP
|Risk Allele=T
|pValue=2.00E-024
|OR=1.76
|95CI=1.49-2.08
}}
{{PMID Auto
|PMID=19384953
|Title=Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
|OA=1
}}

{{omim
|desc=MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 7; CMM7
|id=612263
|rsnum=1015362
}}

{{omim
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 9; SHEP9
|id=611742
|rsnum=1015362
}}

{{omim
|desc=AGOUTI SIGNALING PROTEIN; ASIP
|id=600201
|rsnum=1015362
}}

{{PharmGKB
|RSID=rs1015362
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18488028; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Two newly identified genetic determinants of pigmentation in Europeans (Initial Sample Size: 5,130 individuals; Replication Sample Size: 3,330 individuals; Risk Allele: rs1015362-G + rs4911414-T). This variant is associated with Burning and freckling.
|Drugs=
|Drug Classes=
|Diseases=Skin Abnormalities; Skin Diseases
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356580
}}

Influences [[appearance]] [http://scienceblogs.com/gnxp/2009/03/genetics_of_human_pigmentation.php?utm_source=sbhomepage&utm_medium=link&utm_content=channellink gnxp]

{{PharmGKB
|RSID=rs1015362
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18488027
|Annotation=This variant is associated with the risk of cutaneous melanoma and basal cell carcinoma. It is also strongly associated with pigmentation, freckling and skin sensitivity to sun.
|Drugs=
|Drug Classes=
|Diseases=Carcinoma, Basal Cell; Melanoma
|Curation Level=Curated
|PharmGKB Accession ID=PA162355808
}}

{{PharmGKB
|RSID=rs1015362
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18488028; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Two newly identified genetic determinants of pigmentation in Europeans (Initial Sample Size: 5,130 individuals; Replication Sample Size: 3,330 individuals; Risk Allele: rs1015362-G + rs4911414-T). This variant is associated with Skin sensitivity to sun; freckles and red vs. non-red hair.
|Drugs=
|Drug Classes=
|Diseases=Skin Abnormalities; Skin Diseases
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356582
}}

{{PMID Auto
|PMID=21221757
|Title=ASIP genetic variants and the number of non-melanoma skin cancers
|OA=1
}}

{{PMID|19995372|OA=1
}} Melanoma susceptibility variants on chromosome 20q11.22 are associated with pigmentary traits and the risk of nonmelanoma skin cancer.

{{PMID|20369022|OA=1
}} Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1015362
|overall_frequency_n=49
|overall_frequency_d=128
|overall_frequency=0.382812
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22628150
|Title=Variants at chromosome 20 (ASIP locus) and melanoma risk.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}