{{Rsnum
|rsid=10166942
|Gene=TRPM8
|Chromosome=2
|position=233916448
|Orientation=plus
|GMAF=0.4715
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TRPM8
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 1.8 | 30.6 | 67.6
| HCB | 40.9 | 44.5 | 14.6
| JPT | 31.2 | 42.9 | 25.9
| YRI | 83.7 | 15.6 | 0.7
| ASW | 54.4 | 36.8 | 8.8
| CHB | 40.9 | 44.5 | 14.6
| CHD | 46.3 | 40.7 | 13.0
| GIH | 19.8 | 47.5 | 32.7
| LWK | 87.3 | 12.7 | 0.0
| MEX | 10.3 | 36.2 | 53.4
| MKK | 58.3 | 40.4 | 1.3
| TSI | 4.9 | 22.5 | 72.5
| HapMapRevision=28
}}[[rs10166942]] is a SNP on ch 2q37.1 in the [[TRPM8]] gene.

A large GWAS study of over 5,000 patients with [[migraines]] and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk changes on its own. The odds ratio for the less common [[rs10166942]](C) allele was 0.85 (CI: 0.82 - 0.89, p = 5.5 x 10e-12).{{doi|10.1038/ng.856}}

{{PMID Auto GWAS
|PMID=21666692
|Trait=None
|Title=Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
|RiskAllele=T
|Pval=6E-12
|OR=1.1800
|ORtxt=[1.12-1.22]
|OA=1
}}

{{PMID Auto
|PMID=22072275
|Title=Genetics of migraine in the age of genome-wide association studies
|OA=1
}}

{{PMID Auto GWAS
|PMID=22683712
|Trait=None
|Title=Genome-wide association analysis identifies susceptibility loci for migraine without aura.
|RiskAllele=
|Pval=1E-12
|OR=1.2800
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=24021092
|Title=PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients
}}

{{PMID Auto
|PMID=23294458
|Title=Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine
}}

{{PMID Auto
|PMID=24674449
|Title=A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}