{{Rsnum
|rsid=10181656
|Gene=STAT4
|Chromosome=2
|position=191105153
|Orientation=plus
|GMAF=0.253
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=STAT4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 66.2 | 27.7 | 6.2
| HCB | 42.2 | 46.7 | 11.1
| JPT | 56.8 | 29.5 | 13.6
| YRI | 74.6 | 20.6 | 4.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 42.2 | 46.7 | 11.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}Several tightly linked SNPs in the [[STAT4]] gene have been linked to risk for risk haplotype for systemic lupus erythematosus ([[SLE]]). The strongest association is found for either of two perfectly linked SNP alleles, [[rs10181656]](G) and [[rs7582694]](C), both yielding an odds ratio of 1.71 in this study of ~700 Swedish SLE patients.{{PMID|18579578|OA=1
}}

The risk for SLE was also calculated to increase as a function of the total number of risk alleles for this SNP plus 2 others in the [[IRF5]] gene. Compared to individuals with 0 or 1 risk alleles, the risk for SLE increased 1.82-fold for each additional risk allele from this group. The odds ratio for SLE is 2.08 (CI: 1.53-2.83) for carriers of 2 risk alleles, and goes up to 13.0 (CI: 3.78-44.3) for carriers of 5 or 6 risk alleles (compared to those with 0 or 1).
{{PMID|18579578|OA=1
}}

{{ neighbor
| rsid = 7582694
| distance = 241
}}

{{omim
|desc=RHEUMATOID ARTHRITIS; RA
|id=180300
|rsnum=10181656
}}

{{omim
|id=600558
|desc=SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4; STAT4
|rsnum=10181656
}}
{{PMID Auto
|PMID=19737838
|Title=A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor
}}
{{PMID Auto
|PMID=19762360
|Title=A STAT4 risk allele is associated with ischemic cerebrovascular events and antiphospholipid antibodies in Systemic Lupus Erythematosus
}}

{{PMID Auto
|PMID=20176035
|Title=Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease
}}

{{PMID Auto
|PMID=21683716
|Title=Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population
}}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort
|OA=1
}}

{{PMID|17932559|OA=1
}} Association of STAT4 with rheumatoid arthritis in the Korean population.

{{PMID|18434327|OA=1
}} Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.

{{PMID|18516230|OA=1
}} Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

{{PMID|19120275}} STAT4 polymorphism is associated with early-onset type 1 diabetes, but not with late-onset type 1 diabetes.

{{PMID|19333953|OA=1
}} High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.

{{PMID|19674979|OA=1
}} Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

{{PMID|19717398}} Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort.

{{PMID|20444755|OA=1
}} Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

{{PMID|20454450|OA=1
}} Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

{{PMID|20479942|OA=1
}} Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

{{PMID|22569826}} Abnormal Genetic and Epigenetic Changes in Signal Transducer and Activator of Transcription 4 in the Pathogenesis of Inflammatory Bowel Diseases.

{{PMID Auto
|PMID=22753649
|Title=Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}