{{Rsnum
|rsid=1018381
|Gene=DTNBP1
|Chromosome=6
|position=15656839
|Orientation=minus
|GMAF=0.1423
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DTNBP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 78.5 | 20.0 | 1.5
| HCB | 88.9 | 11.1 | 0.0
| JPT | 84.1 | 13.6 | 2.3
| YRI | 44.4 | 52.4 | 3.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 88.9 | 11.1 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[http://genes2brains2mentalhealth.wordpress.com/2007/12/21/i-carry-genetic-risk-for-mental-illness/ g2b2mh blog] In a population of healthy individuals, those that carry common variants (such as [[rs760761]], [[rs1018381]], [[rs2619522]]) located in the dysbindin (DTNBP1) gene, a risk factor for [[schizophrenia]], show minor cognitive impairments such as decreased attentional capacity, worse performance on [[memory]] tasks, and alterations in schizotypal beliefs and experiences.

{{PMID Auto
|PMID=19335929
|Title=Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects.
}}

{{PMID Auto
|PMID=19497374
|Title=Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals
}}

{{PMID Auto
|PMID=19077176
|Title=Variation in the dysbindin gene and normal cognitive function in three independent population samples
}}

{{omim
|desc=DYSTROBREVIN-BINDING PROTEIN 1; DTNBP1
|id=607145
|rsnum=1018381
}}
{{PMID Auto
|PMID=19621369
|Title=The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval
}}
{{PMID Auto
|PMID=19650139
|Title=Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals
}}

{{PMID Auto
|PMID=20846375
|Title=The effects of a DTNBP1 gene variant on attention networks: an fMRI study
|OA=1
}}
{{PMID Auto
|PMID=21130223
|Title=Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability
|OA=1
}}

{{PMID Auto
|PMID=12098102
|Title=Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=12474144
|Title=Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.
|OA=1
}}

{{PMID Auto
|PMID=14618545
|Title=The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease.
|OA=1
}}

{{PMID Auto
|PMID=15290652
|Title=A powerful strategy to account for multiple testing in the context of haplotype analysis.
|OA=1
}}

{{PMID Auto
|PMID=15362017
|Title=Association of the DTNBP1 locus with schizophrenia in a U.S. population.
|OA=1
}}

{{PMID Auto
|PMID=17033966
|Title=Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17074466
|Title=DTNBP1 genotype influences cognitive decline in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17445278
|Title=Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.
|OA=1
}}

{{PMID Auto
|PMID=18663367
|Title=The dystrobrevin-binding protein 1 gene: features and networks.
|OA=1
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=18797396
|Title=Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression.
}}

{{PMID Auto
|PMID=18804346
|Title=Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19369910
|Title=The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.
|OA=1
}}

{{PMID Auto
|PMID=19862852
|Title=Association study of DTNBP1 with schizophrenia in a US sample.
|OA=1
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=22019876
|Title=The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: a TBSS-based diffusion tensor imaging study.
}}

{{PMID Auto
|PMID=22580710
|Title=The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.
|OA=1
}}

{{PMID Auto
|PMID=22911901
|Title=Association of genetic variations in DTNBP1 with cognitive function in schizophrenia patients and healthy subjects.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}