{{Rsnum
|rsid=1021737
|Gene=CTH
|Chromosome=1
|position=70439117
|Orientation=plus
|GMAF=0.2259
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=CTH
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 54.5 | 38.4 | 7.1
| HCB | 62.2 | 31.9 | 5.9
| JPT | 59.3 | 36.3 | 4.4
| YRI | 87.1 | 12.9 | 0.0
| ASW | 71.9 | 28.1 | 0.0
| CHB | 62.2 | 31.9 | 5.9
| CHD | 71.6 | 23.9 | 4.6
| GIH | 56.4 | 38.6 | 5.0
| LWK | 86.2 | 13.8 | 0.0
| MEX | 27.6 | 50.0 | 22.4
| MKK | 91.0 | 9.0 | 0.0
| TSI | 58.4 | 39.6 | 2.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1021737
|Name_s=CTH: c.1352G>T; p.S403I
|Gene_s=CTH
|Feature=
|Evidence=PubMed ID:15151507
|Annotation=Homozygotes for this variant allele in the CTH gene had significantly higher plasma homocysteine levels than other genotypes in a cohort of 496 Caucasian individuals.
|Drugs=
|Drug Classes=
|Diseases=Hyperhomocysteinemia
|Curation Level=Curated
|PharmGKB Accession ID=PA164920417
}}

{{omim
|id=607657
|rsnum=1021737
|variant=0005
}}

{{ClinVar
|rsid=1021737
|Reversed=0
|FwdREF=G
|FwdALT=T
|REF=G
|ALT=T
|RSPOS=70439117
|CHROM=1
|GMAF=0.2271
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050368000a0515051f110100
|GENEINFO=CTH:1491
|GENE_NAME=CTH
|GENE_ID=1491
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.70439117G>T
|CLNORIGIN=1
|CLNSIG=5
|Tags=PM;PMC;S3D;SLO;NSM;REF;ASP;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7741; 0.2259
|CLNACC=RCV000003075.1
|CLNDBN=Homocysteine, total plasma, elevated
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNSRCID=NM_001902.5:c.1208G>T; 607657.0005
|COMMON=1
|Disease=Homocysteine
}}

{{PMID Auto
|PMID=18701025
|Title=Relationship between cystathionine gamma-lyase gene polymorphism and essential hypertension in Northern Chinese Han population.
}}

{{PMID Auto
|PMID=19048631
|Title=Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.
|OA=1
}}

{{GET Evidence
|gene=CTH
|aa_change=Ser403Ile
|aa_change_short=S403I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1021737
|overall_frequency_n=2553
|overall_frequency_d=10758
|overall_frequency=0.237312
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=5
|autoscore=2
|n_web_uneval=10
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}