{{Rsnum
|rsid=1022563
|Chromosome=20
|position=1973693
|Orientation=plus
|GMAF=0.3471
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=opioid dependence in females
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=RP4-684O24.5
|Gene_s=RP4-684O24.5
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 80.0 | 20.0 | 0.0
| HCB | 4.4 | 17.8 | 77.8
| JPT | 11.4 | 38.6 | 50.0
| YRI | 74.6 | 19.0 | 6.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 4.4 | 17.8 | 77.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
This SNP is associated with opioid dependence and [[addiction]] in females. The risk allele is the minor allele, [[rs1022563]](T).

{{PMID Auto
|PMID=19298317
|Title=An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population
}}

{{PMID Auto
|PMID=21382455
|Title=Association between heroin dependence and prodynorphin gene polymorphisms
}}
{{PMID Auto
|PMID=22443215
|Title=Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}