{{Rsnum
|rsid=1024611
|Gene=CCL2
|Chromosome=17
|position=34252769
|Orientation=plus
|GMAF=0.4054
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.3 | 50.4 | 44.2
| HCB | 38.7 | 46.7 | 14.6
| JPT | 38.9 | 51.3 | 9.7
| YRI | 4.8 | 29.3 | 66.0
| ASW | 7.0 | 36.8 | 56.1
| CHB | 38.7 | 46.7 | 14.6
| CHD | 33.3 | 43.5 | 23.1
| GIH | 8.9 | 36.6 | 54.5
| LWK | 4.5 | 41.8 | 53.6
| MEX | 24.1 | 46.6 | 29.3
| MKK | 4.5 | 32.7 | 62.8
| TSI | 4.9 | 45.1 | 50.0
| HapMapRevision=28
}}[[rs1024611]], also known as the -2578A>G SNP due to its position in the promoter of the monocyte chemoattractant protein-1 MCP-1 [[CCL2]] gene, influences the production of its corresponding protein, a chemokine involved in inflammatory responses.

In a study focusing on 679 apparently healthy siblings of people with premature [[heart disease]], investigators found that carriers of an [[rs1024611]](C) allele - oriented as in dbSNP, not as published - independently predicted the risk of exercise induced ischemia in general. The odds ratio was reported to be 1.86 (CI: 1.14-3.04, p=0.014), regardless of race, age, sex and other factors. However, it is not clear if this risk carries over to individuals who lack siblings with [[heart disease]].{{PMID|16934270}}

discussed in the [http://blog.23andme.com/2008/07/16/snpwatch-genetic-variant-common-in-african-americans-may-influence-susceptibility-to-hiv/ 23andMe blog] as being relevant to [[HIV]] 

{{PMID|19032966}} [[rs1024611]] is not associated with systemic sclerosis in a multicenter study of 345 European patients

{{PMID Auto
|PMID=23166687
|rsnum= rs1024611 
|Title=[The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance] 
|OA=1
}}

{{omim
|desc=CHEMOKINE, CC MOTIF, LIGAND 2; CCL2
|id=158105
|rsnum=1024611
|variant=0003
}}

{{omim
|desc=MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
|id=607948
|rsnum=1024611
}}
[[tuberculosis]]

{{PMID Auto
|PMID=22142522
|Title=Lack of Association between rs1024611 (-2581 A/G) Polymorphism in CC-chemokine Ligand 2 and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran
}}

{{PMID Auto
|PMID=22117412
|Title=[Association of polymorphic markers of CCL2 gene with essential hypertension]
}}

{{PMID Auto
|PMID=22384203
|Title=MCP1 SNPs and Pulmonary Tuberculosis in Cohorts from West Africa, the USA and Argentina: Lack of Association or Epistasis with IL12B Polymorphisms
|OA=1
}}

{{PMID Auto
|PMID=22733495
|Title=Association of inflammatory chemokine gene CCL2I/D with bladder cancer risk in North Indian population
}}

{{PMID|16078996|OA=1
}} Association study of functional genetic variants of innate immunity related genes in celiac disease.

{{PMID|16672419|OA=1
}} Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.

{{PMID|16719905|OA=1
}} Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

{{PMID|17062130|OA=1
}} Polymorphisms within inflammatory genes and colorectal cancer.

{{PMID|17763208}} Association of the -2510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population.

{{PMID|17848170|OA=1
}} The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.

{{PMID|17903293|OA=1
}} Genome-wide association with select biomarker traits in the Framingham Heart Study.

{{PMID|18464913|OA=1
}} A genome-wide association study identifies protein quantitative trait loci (pQTLs).

{{PMID|18698231|OA=1
}} Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

{{PMID|18940815|OA=1
}} MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa.

{{PMID|19347053|OA=1
}} Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

{{PMID|19357773|OA=1
}} Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

{{PMID|19506371|OA=1
}} Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis.

{{PMID|20111728|OA=1
}} Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals.

{{PMID|20111745|OA=1
}} Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.

{{PMID|20125127}} The -A2518G polymorphism of monocyte chemoattractant protein-1 is associated with Crohn's disease.

{{PMID|20196868|OA=1
}} Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

{{PMID|20339010}} CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage.

{{PMID|20622166|OA=1
}} Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.

{{PMID|20725607|OA=1
}} CCL3 genotype and current depression increase risk of HIV-associated dementia.

{{PMID|20811626|OA=1
}} Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

{{PMID|22425139}} Monocyte chemoattractant protein-1 in schizophrenia: -2518A/G genetic variant and protein levels in Armenian population.

{{PMID Auto
|PMID=23166687
|Title=The rs1024611 Regulatory Region Polymorphism Is Associated with CCL2 Allelic Expression Imbalance
|OA=1
}}

{{PMID Auto
|PMID=23427179
|Title=Relationships of Single Nucleotide Polymorphisms of Monocyte Chemoattractant Protein 1 and Chemokine Receptor 2 With Susceptibility and Clinicopathologic Characteristics of Neoplasia of Uterine Cervix in Taiwan Women
}}

{{PMID Auto
|PMID=24023637
|Title=Gender-Specific Effects of Genetic Variants within Th1 and Th17 Cell-Mediated Immune Response Genes on the Risk of Developing Rheumatoid Arthritis
|OA=1
}}

{{PMID Auto
|PMID=24083412
|Title=Functional Genetic Polymorphisms of Monocyte Chemoattractant Protein 1 and C-C Chemokine Receptor Type 2 in Ischemic Stroke
}}

{{PMID Auto
|PMID=24382482
|Title=Polymorphism of monocyte chemoattractant protein -1 (MCP-1 -2518 A/G) and responsiveness to hepatitis B vaccination in hemodialysis patients
}}

{{PMID Auto
|PMID=24786287
|Title=No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population
}}

{{PMID Auto
|PMID=24968246
|Title=Relationship between MCP-1 promoter -2518 A/G gene polymorphism (rs1024611) and systemic lupus erythematosus/lupus nephritis
}}

{{PMID Auto
|PMID=25119828
|Title=The CC chemokine ligand 2 (CCL2) polymorphism -2518A/G is associated with gout in the Chinese Han male population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}