{{Rsnum
|rsid=10246939
|Gene=TAS2R38
|Chromosome=7
|position=141972804
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.4509
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MGAM,TAS2R38
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 47.8 | 32.7
| HCB | 46.7 | 41.6 | 11.7
| JPT | 34.5 | 46.0 | 19.5
| YRI | 20.7 | 51.0 | 28.3
| ASW | 29.8 | 54.4 | 15.8
| CHB | 46.7 | 41.6 | 11.7
| CHD | 50.9 | 41.7 | 7.4
| GIH | 16.0 | 52.0 | 32.0
| LWK | 25.7 | 49.5 | 24.8
| MEX | 37.9 | 44.8 | 17.2
| MKK | 26.3 | 48.1 | 25.6
| TSI | 32.4 | 45.1 | 22.5
| HapMapRevision=28
}}[[rs10246939]] is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the [[taste]] of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like [[coffee]] and dark beers).

The [[rs10246939]](C) allele, in the orientation shown in dbSNP, is the "tasting" allele, and it is dominant to the "non-tasting" allele [[rs10246939]](T), so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one [[rs713598]](G) and one [[rs1726866]](C) allele since, along with [[rs10246939]](C), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.{{PMID|12595690}} 

{{ neighbor
| rsid = 1726866
| distance = 101
}}

{{omim
|desc=TASTE RECEPTOR, TYPE 2, MEMBER 38; TAS2R38
|id=607751
|rsnum=10246939
|variant=0003
}}

{{PMID Auto
|PMID=20675712
|Title=The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
|OA=1
}}

{{ClinVar
|rsid=10246939
|Reversed=0
|FwdREF=T
|FwdALT=C
|REF=T
|ALT=C
|RSPOS=141672604
|CHROM=7
|GMAF=0.4515
|dbSNPBuildID=119
|SSR=0
|SAO=1
|VP=0x05016800000017051f110100
|GENEINFO=TAS2R38:5726
|GENE_NAME=TAS2R38
|GENE_ID=5726
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.141672604T>C
|CLNSIG=6
|Tags=PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.4509; 0.5491
|CLNACC=RCV000003040.1
|CLNDBN=Phenylthiocarbamide tasting
|CLNDSDB=MedGen
|CLNDSDBID=C1868398
|CLNORIGIN=1
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=607751.0003
|COMMON=1
|Disease=Phenylthiocarbamide tasting
}}

{{PMID Auto
|PMID=18248681
|Title=Prevalence of common disease-associated variants in Asian Indians.
|OA=1
}}

{{PMID Auto
|PMID=18834969
|Title=A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.
|OA=1
}}

{{PMID Auto
|PMID=19779476
|Title=Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.
|OA=1
}}

{{GET Evidence
|gene=TAS2R38
|aa_change=Ile296Val
|aa_change_short=I296V
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10246939
|overall_frequency_n=4985
|overall_frequency_d=10758
|overall_frequency=0.463376
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=59
|n_articles=2
|n_articles_annotated=2
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|qualityscore_case_control=2
|qualitycomment_case_control=Y
|in_omim=Y
|pph2_score=0.984
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-4
|autoscore=5
|webscore=N
|variant_evidence=0
|clinical_importance=0
|summary_short=This variant is associated with "taster" status of PTC, along with 49P and 262A. Due to linkage disequilibrium, the independent effects of positions 296 and 262 is unclear. The presence of 49P confers taster status in a dominant fashion, but in the absence of 49P, the presence of 262A/296V is still positively associated with tasting PTC.
}}

{{PMID Auto
|PMID=24083639
|Title=Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk
}}

{{PMID Auto
|PMID=23133589
|Title=Bitter taste receptor polymorphisms and human aging.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}