{{Rsnum
|rsid=10260404
|Gene=DPP6
|Chromosome=7
|position=154513713
|Orientation=plus
|GMAF=0.2888
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DPP6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 48.7 | 31.9
| HCB | 2.9 | 35.0 | 62.0
| JPT | 0.0 | 27.4 | 72.6
| YRI | 9.5 | 44.9 | 45.6
| ASW | 8.8 | 33.3 | 57.9
| CHB | 2.9 | 35.0 | 62.0
| CHD | 2.8 | 32.1 | 65.1
| GIH | 14.9 | 47.5 | 37.6
| LWK | 10.9 | 44.5 | 44.5
| MEX | 8.6 | 46.6 | 44.8
| MKK | 5.8 | 30.1 | 64.1
| TSI | 17.8 | 48.5 | 33.7
| HapMapRevision=28
}}
[[rs10260404]], a SNP in the region of the [[DPP6]] gene on chromosome 7, has been associated with the sporadic form of [[ALS]] (Lou Gehrig's disease) in a study of 1000+ European patients. The overall odds ratio for the risk allele [[rs10260404(C)]] is 1.30 (CI: 1.18-1.43, p=0.017). When broken down by genotype, the odds ratios for heterozygotes are 1.20 (CI: 1.06-1.41), and for [[rs10260404]](C;C) homozygotes, 1.60 (CI: 1.32-1.92).{{PMID|18084291}}

A "C-C" haplotype for this SNP and that of it's neighbor [[rs10239794]] is also highly (statistically; p=10e-9) associated with [[ALS]]. {{PMID|18084291}}

However, in an expanded study pooling 4 populations (Irish, Dutch, US, Polish) [[rs10260404]] failed to reach Bonferroni significance. although it did remain significant in the (expanded) Irish-only population.{{PMID|18987618|OA=1
}}

{{GWAS Summary
|SNP=rs10260404
|PubMedID=18057069
|Condition=Amyotrophic lateral sclerosis
|Gene=DPP6
|Risk Allele=
|pValue=3.00E-006
|OR=1.37
|95CI=1.20-1.56
}}

{{PharmGKB
|RSID=rs10260404
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18987618; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Screening for replication of genome-wide SNP associations in sporadic AL. (Initial Sample Size: 958 cases, 932 controls; Replication Sample Size: 309 cases, 404 controls); (Region: 7q36.2; Reported Gene(s): DPP6; Risk Allele: rs10260404-C); (p-value= 0.000003).This variant is associated with Amyotrophic lateral sclerosis.
|Drugs=
|Drug Classes=
|Diseases=Amyotrophic Lateral Sclerosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740748
}}

{{PharmGKB
|RSID=rs10260404
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18084291
|Annotation=In a GWAS, this SNP in the DPP6 gene was strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS).
|Drugs=
|Drug Classes=
|Diseases=Amyotrophic Lateral Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA161889380
}}

{{PharmGKB
|RSID=rs10260404
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18057069; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study of sporadic ALS in a homogenous Irish population (Initial Sample Size: 221 cases, 211 controls; Replication Sample Size: 737 cases, 721 controls). This variant is associated with Amyotrophic lateral sclerosis.
|Drugs=
|Drug Classes=
|Diseases=Amyotrophic Lateral Sclerosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356390
}}

{{PharmGKB
|RSID=rs10260404
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18084291; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis (Initial Sample Size: 737 cases, 721 controls; Replication Sample Size: 1,030 cases, 1,195 controls; Risk Allele: rs10260404-C).
|Drugs=
|Drug Classes=
|Diseases=Amyotrophic Lateral Sclerosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356702
}}

{{PMID Auto
|PMID=19193627
|Title=A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19525032
|Title=No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
}}

{{PMID Auto
|PMID=20137488
|Title=Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10260404
|overall_frequency_n=35
|overall_frequency_d=128
|overall_frequency=0.273438
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22795786
|Title=No association of five candidate genetic variants with amyotrophic lateral sclerosis in a Chinese population
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}