{{Rsnum
|rsid=1026732
|Gene=MAP2K5
|Chromosome=15
|position=67802747
|Orientation=plus
|GMAF=0.4913
|Gene_s=MAP2K5
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.5 | 48.2 | 47.3
| HCB | 48.2 | 46.7 | 5.1
| JPT | 52.2 | 38.1 | 9.7
| YRI | 20.4 | 52.4 | 27.2
| ASW | 24.6 | 42.1 | 33.3
| CHB | 48.2 | 46.7 | 5.1
| CHD | 47.7 | 42.2 | 10.1
| GIH | 26.7 | 43.6 | 29.7
| LWK | 15.5 | 49.1 | 35.5
| MEX | 37.9 | 48.3 | 13.8
| MKK | 9.6 | 42.3 | 48.1
| TSI | 13.9 | 40.6 | 45.5
| HapMapRevision=28
}}[[rs1026732]], a SNP located in a region of chromosome 15q, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.70 (CI: 0.59-0.82) for the (A) minor allele. {{PMID|17637780}}

{{PharmGKB
|RSID=rs1026732
|Name_s=
|Gene_s=MAP2K5
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs1026732 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355633
}}

{{PMID Auto
|PMID=19279021
|Title=Replication of restless legs syndrome loci in three European populations.
|OA=1
}}

{{PMID Auto
|PMID=20396431
|Title=Genotyping sleep disorders patients.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1026732
|overall_frequency_n=59
|overall_frequency_d=126
|overall_frequency=0.468254
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=55
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}