{{Rsnum
|rsid=10306114
|Gene=PTGS1
|Chromosome=9
|position=122370243
|Orientation=plus
|GMAF=0.05923
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PTGS1
}}[[rs10306114]], also known as -842A>G, is a SNP upstream of the cyclooxygenase-1 [[PTGS1]] gene.

A study of 696 European patients undergoing elective diagnostic coronary angiographies (CAGs) because of suspected or proven stable coronary artery disease found that 23 experienced bleeding, perhaps the most common complication of this type of invasive coronary procedure. After controlling for various variables (especially gender), two co-inherited SNPs, [[rs10306114]] and [[rs3842787]], were found to be associated with higher risk for bleeding in otherwise low risk patients who (i) did undergo percutaneous coronary intervention and (ii) did not take [[clopidogrel]]. Having the less common haplotype ([[rs10306114]](G) and/or [[rs3842787]](T)) increases the bleeding risk upon CAG ~12 fold (p = 0.012).{{PMID|20691446}}   

{{PMID Auto
|PMID=19786296
|Title=Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction
}}

{{PMID Auto
|PMID=17301694
|Title=Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).
|OA=1
}}

{{PMID Auto
|PMID=17495879
|Title=Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.
|OA=1
}}

{{PMID Auto
|PMID=19046748
|Title=Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}