{{Rsnum
|rsid=1031681
|Chromosome=12
|position=84526555
|Orientation=minus
|GMAF=0.4284
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.1 | 46.8 | 36.0
| HCB | 9.5 | 38.7 | 51.8
| JPT | 4.4 | 25.7 | 69.9
| YRI | 26.7 | 49.3 | 24.0
| ASW | 25.0 | 57.1 | 17.9
| CHB | 9.5 | 38.7 | 51.8
| CHD | 4.6 | 41.3 | 54.1
| GIH | 32.7 | 50.0 | 17.3
| LWK | 0.0 | 0.0 | 0.0
| MEX | 30.9 | 52.7 | 16.4
| MKK | 39.7 | 47.7 | 12.6
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs1031681]] is one of two linked SNPs potentially associated (at a distance though) with the [[SLC6A15]] gene; the other is [[rs1545843]].

A GWAS study and meta-analysis ultimately including six independent samples, primarily Caucasion/European but also including an African-American sample, found that the [[rs1031681]](A) allele was associated with higher risk for major [[depression]], but only in individuals less than 55 years old and only when homozygous, with an odds ratio of 1.3 (p = 5 x 10e-5).{{PMID|21521612|OA=1
}}

{{on chip | Affy GenomeWide 6}}