{{Rsnum
|rsid=10380
|Gene=MTRR
|Chromosome=5
|position=7897078
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.1901
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MTRR
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 70.5 | 27.7 | 1.8
| HCB | 69.3 | 29.2 | 1.5
| JPT | 77.9 | 21.2 | 0.9
| YRI | 37.4 | 49.0 | 13.6
| ASW | 54.4 | 36.8 | 8.8
| CHB | 69.3 | 29.2 | 1.5
| CHD | 67.0 | 27.5 | 5.5
| GIH | 72.3 | 24.8 | 3.0
| LWK | 43.6 | 50.0 | 6.4
| MEX | 51.7 | 36.2 | 12.1
| MKK | 61.5 | 35.3 | 3.2
| TSI | 74.5 | 23.5 | 2.0
| HapMapRevision=28
}}{{PMID|18515090}}  [[pancreatic cancer]]  702 cases and 785 controls
*[[rs162049]] P = .0018; OR, 1.33; 95% CI: 1.11-1.60 
*[[rs10380]] (His595Tyr) P = .0063; OR, 1.45; 95% CI: 1.11-1.88

{{PMID Auto
|PMID=19493349
|Title=118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
|OA=1
}}

{{PMID Auto
|PMID=21211571
|Title=MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic
}}

{{PMID Auto
|PMID=19064578
|Title=No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=20445798
|Title=Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.
|OA=1
}}

{{GET Evidence
|gene=MTRR
|aa_change=His622Tyr
|aa_change_short=H622Y
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10380
|overall_frequency_n=1876
|overall_frequency_d=10758
|overall_frequency=0.174382
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-1
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22957669
|Title=Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}