{{Rsnum
|rsid=1038304
|Gene=C6orf97
|Chromosome=6
|position=151612040
|Orientation=plus
|GMAF=0.4568
|Gene_s=CCDC170
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 27.4 | 54.9 | 17.7
| HCB | 24.3 | 55.1 | 20.6
| JPT | 35.4 | 43.4 | 21.2
| YRI | 3.5 | 16.7 | 79.9
| ASW | 5.4 | 39.3 | 55.4
| CHB | 24.3 | 55.1 | 20.6
| CHD | 27.8 | 51.9 | 20.4
| GIH | 26.7 | 51.5 | 21.8
| LWK | 0.0 | 7.6 | 92.4
| MEX | 39.7 | 37.9 | 22.4
| MKK | 1.3 | 29.9 | 68.8
| TSI | 26.5 | 47.1 | 26.5
| HapMapRevision=28
}}

{{Report GE
|PubMed=18445777
|Source=journal
|AffyProbeset=SNP_A-1988119
|AffyOrientation=same
|AlleleA=A
|AlleleB=G
|onGW5=
|rsid=1038304
|ancestral=G
|RiskPopulation=Caucasian
|RiskAllele=G
|CaseFreq=
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=-
|Disease=Bone mineral density, lower
|DiseaseSymbol=BMD-L
}}

rs1038304 increases susceptibility to Bone mineral density variations, lower for carriers of the G allele {{PMID|18445777}}

{{GWAS Summary
|SNP=rs1038304
|PubMedID=18445777
|Condition=Bone mineral density (hip)
|Gene=ESR1
|Risk Allele=G
|pValue=5.00E-009
|OR=0.08
|95CI=0.06-0.11) SD decreas
}}

{{PMID Auto GWAS
|PMID=19079262
|Trait=Bone mineral density (hip)
|Title=New sequence variants associated with bone mineral density
|RiskAllele=G
|Pval=4E-10
|OR=0.08
|ORtxt=[0.06-0.11] SD decrease
}}

{{omim
|desc=BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 11; BMND11
|id=612114
|rsnum=1038304
}}

{{PharmGKB
|RSID=rs1038304
|Name_s=
|Gene_s=C6orf97
|Feature=
|Evidence=PubMed ID:19079262; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New sequence variants associated with bone mineral density. (Initial Sample Size: 6,865 individuals; Replication Sample Size: 8,510 individuals); (Region: 6q25.1; Reported Gene(s): ESR1; Risk Allele: rs1038304-G); (p-value= 0.0000000004).This variant is associated with Bone mineral density (hip).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740130
}}

{{PharmGKB
|RSID=rs1038304
|Name_s=
|Gene_s=C6orf97
|Feature=
|Evidence=PubMed ID:18445777; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple Genetic Loci for Bone Mineral Density and Fractures (Initial Sample Size: 5,861 individuals; Replication Sample Size: 7,925 individuals; Risk Allele: rs1038304-G). This variant is associated with Bone mineral density (hip).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic; Fractures, Bone
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356555
}}

{{PMID Auto
|PMID=21528353
|Title=Genetic variants of 6q25 and breast cancer susceptibility: a two-stage fine mapping study in a Chinese population
}}

{{PMID Auto
|PMID=21646926
|Title=Interactions of osteoporosis candidate genes for age at menarche, age at natural menopause, and maximal height in Han Chinese women
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=20072603
|Title=Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
|OA=1
}}

{{PMID Auto
|PMID=20534768
|Title=OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1038304
|overall_frequency_n=81
|overall_frequency_d=128
|overall_frequency=0.632812
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24481879
|Title=Association of ESR1 and C6orf97 gene polymorphism with osteoporosis in postmenopausal women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}