{{Rsnum
|rsid=10399805
|Gene=CHI3L1
|Chromosome=1
|position=203186870
|Orientation=plus
|GMAF=0.2778
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHI3L1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 25.9 | 71.4
| HCB | 11.1 | 39.3 | 49.6
| JPT | 17.1 | 41.4 | 41.4
| YRI | 27.2 | 38.1 | 34.7
| ASW | 17.5 | 50.9 | 31.6
| CHB | 11.1 | 39.3 | 49.6
| CHD | 10.2 | 38.9 | 50.9
| GIH | 1.0 | 22.0 | 77.0
| LWK | 25.5 | 43.6 | 30.9
| MEX | 6.9 | 37.9 | 55.2
| MKK | 18.6 | 46.8 | 34.6
| TSI | 1.0 | 21.6 | 77.5
| HapMapRevision=28
}}{{PMID|18281018}}  [[schizophrenia]]
*375 case and 812 control subjects
*[[rs10399805]] p = .018 and [[rs2275351]]; p = .008.

{{PMID|18767121}} An attempt to repeat the association between [[rs10399805]] and risk for [[schizophrenia]] in an ethnically identical population (Japanese) as well as a new population (Han Chinese) failed to show any significant association.

{{PMID|19106306}} rs10399805(T;T) genotype showed a 2.5-fold increase in CHI3L1 mRNA expression in peripheral blood cells than those with (C;C) which is associated with the risk of atopy.

{{ neighbor
| rsid = 4950928
| distance = 116
}}

{{PharmGKB
|RSID=rs10399805
|Name_s=
|Gene_s=CHI3L1
|Feature=
|Evidence=PubMed ID:18281018
|Annotation=In a sample of 375 case and 812 control subjects a significant association of schizophrenia with this SNP (rs10399805) in the promoter region of CHI3L1 was identified. The variant is located at position -247 and disrupts the C/EBP-AML-1 binding site in the gene promoter. The risk allele is predicted to increase CHI3L1 expression.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162565807
}}
{{PMID Auto
|PMID=20051317
|Title=The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis
}}

{{PMID Auto
|PMID=17160890
|Title=Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=18403759
|Title=Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
|OA=1
}}

{{PMID Auto
|PMID=19568425
|Title=Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.
|OA=1
}}

{{PMID Auto
|PMID=21257319
|Title=Genetic polymorphisms in chitinase 3-like 1 (CHI3L1) are associated with circulating YKL-40 levels, but not with angiographic coronary artery disease in a Chinese population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10399805
|overall_frequency_n=29
|overall_frequency_d=124
|overall_frequency=0.233871
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=25203433
|Title=Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms and Haplotypes with Uterine Cervical Cancer in Taiwanese Women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}