{{Rsnum
|rsid=10411210
|Gene=RHPN2
|Chromosome=19
|position=33041394
|Orientation=plus
|GMAF=0.213
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=RHPN2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 83.2 | 16.8 | 0.0
| HCB | 63.5 | 35.0 | 1.5
| JPT | 75.2 | 23.0 | 1.8
| YRI | 33.3 | 45.6 | 21.1
| ASW | 35.1 | 47.4 | 17.5
| CHB | 63.5 | 35.0 | 1.5
| CHD | 67.0 | 29.4 | 3.7
| GIH | 40.6 | 51.5 | 7.9
| LWK | 27.3 | 42.7 | 30.0
| MEX | 62.1 | 36.2 | 1.7
| MKK | 26.3 | 50.0 | 23.7
| TSI | 82.2 | 14.9 | 3.0
| HapMapRevision=28
}}
[http://www.nature.com/ng/journal/v40/n12/abs/ng.262.html nature] [[colorectal cancer]]
[[rs10411210]] RHPN2; P = 4.6 times 10-9)

In a replication study of ~1,800 Swedish patients, the [[rs10411210]](T) allele was specifically also shown to be associated with younger age of onset for [[colorectal cancer]].{{PMID|20648012|OA=1
}}

{{PMID Auto GWAS
|PMID=19011631
|Trait=Colorectal cancer
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
|RiskAllele=C
|Pval=5E-9
|OR=1.15
|ORtxt=[1.10-1.20]
|OA=1
}}

{{omim
|desc=COLORECTAL CANCER, SUSCEPTIBILITY TO, 10; CRCS10
|id=612591
|rsnum=10411210
}}

{{PharmGKB
|RSID=rs10411210
|Name_s=
|Gene_s=RHPN2
|Feature=
|Evidence=PubMed ID:19011631; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. (Initial Sample Size: 1,902 cases, 1,929 controls; Replication Sample Size: 4,878 cases, 4,914 controls); (Region: 19q13.11; Reported Gene(s): RHPN2; Risk Allele: rs10411210-C); (p-value= 0.000000005).This variant is associated with Colorectal cancer.
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740332
}}

{{PharmGKB
|RSID=rs10411210
|Name_s=
|Gene_s=RHPN2
|Feature=
|Evidence=PubMed ID:19011631
|Annotation=A meta-analysis of two GWA studies identified this variant at 19q13.1 (RHPN2) as a risk locus for colorectal cancer.
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162360102
}}
{{PMID Auto
|PMID=21119214
|Title=Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
|OA=1
}}

{{PMID Auto
|PMID=22363440
|Title=cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue
|OA=1
}}

{{PMID Auto
|PMID=22367214
|Title=Characterization of gene-environment interactions for colorectal cancer susceptibility loci
|OA=1
}}

{{PMID|19639606|OA=1
}} Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

{{PMID|20501757|OA=1
}} Low-penetrance susceptibility variants in familial colorectal cancer.

{{PMID|21071539|OA=1
}} Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.

{{PMID|21314996|OA=1
}} Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

{{PMID|22045029}} Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.

{{PMID|22235025}} Susceptibility genetic variants associated with early-onset colorectal cancer.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10411210
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23359760
|Title=Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
|OA=1
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{PMID Auto
|PMID=22999960
|Title=Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
|OA=1
}}

{{PMID Auto
|PMID=23434150
|Title=Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
|OA=1
}}

{{PMID Auto
|PMID=24854447
|Title=Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population
}}

{{PMID Auto
|PMID=25021488
|Title=PWE-010 The Association Of Tgfb Signalling Pathway Gene Polymorphisms With Colorectal Cancer Risk: A Meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}