{{Rsnum
|rsid=1042031
|Gene=APOB
|Chromosome=2
|position=21002881
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1529
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=APOB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.3 | 27.9 | 65.8
| HCB | 0.0 | 5.8 | 94.2
| JPT | 0.0 | 8.0 | 92.0
| YRI | 4.1 | 25.2 | 70.7
| ASW | 3.5 | 26.3 | 70.2
| CHB | 0.0 | 5.8 | 94.2
| CHD | 0.0 | 6.4 | 93.6
| GIH | 4.0 | 10.9 | 85.1
| LWK | 4.5 | 33.6 | 61.8
| MEX | 1.7 | 32.8 | 65.5
| MKK | 1.3 | 14.7 | 84.0
| TSI | 1.0 | 32.4 | 66.7
| HapMapRevision=28
}}{{Venter SNP
|rsid=1042031
|allele=T
|frequency=0.208
|uid=1103658040694
|type=homozygous_SNP
|hugo=APOB
|ensembl gene=ENSG00000084674
|ensembl transcript=ENST00000381043
|sift=TOLERATED
|disease=Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.
}}

{{ neighbor
| rsid = 1042034
| distance = 472
}}

{{PMID Auto
|PMID=20724655
|Title=ApoB genetic variants modify the response to fenofibrate: a GOLDN study
|OA=1
}}

{{PMID Auto
|PMID=21855833
|Title=Replication of Genetic Association Studies in Aortic Stenosis in Adults
}}

{{PMID Auto
|PMID=16642433
|Title=Polymorphism in maternal LRP8 gene is associated with fetal growth.
|OA=1
}}

{{PMID Auto
|PMID=18078817
|Title=Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.
|OA=1
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=20018037
|Title=Mendelian randomization in family data.
|OA=1
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{GET Evidence
|gene=APOB
|aa_change=Glu4181Lys
|aa_change_short=E4181K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1042031
|overall_frequency_n=1793
|overall_frequency_d=10758
|overall_frequency=0.166667
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=0
|autoscore=2
|n_web_uneval=2
}}

{{PMID Auto
|PMID=23444115
|Title=Associations of polymorphisms of rs693 and rs1042031 in apolipoprotein B gene with risk of breast cancer in Chinese.
}}

{{PMID Auto
|PMID=24903972
|Title=Genetic predisposition to calcific aortic stenosis and mitral annular calcification
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}