{{Rsnum
|rsid=1042580
|Gene=THBD
|Chromosome=20
|position=23046984
|Orientation=minus
|GMAF=0.2801
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=THBD
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 42.0 | 41.1 | 17.0
| HCB | 61.5 | 31.9 | 6.7
| JPT | 67.6 | 25.2 | 7.2
| YRI | 65.8 | 30.8 | 3.4
| ASW | 73.7 | 26.3 | 0.0
| CHB | 61.5 | 31.9 | 6.7
| CHD | 72.5 | 19.3 | 8.3
| GIH | 33.3 | 40.4 | 26.3
| LWK | 56.0 | 42.2 | 1.8
| MEX | 44.6 | 44.6 | 10.7
| MKK | 41.3 | 51.0 | 7.7
| TSI | 45.1 | 43.1 | 11.8
| HapMapRevision=28
}}[http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pgen.0030120.eor linked] to Cardiovascular Events

Several CVD risk variants were identified: In women, the combination of F5 [[rs7542281]] Ã— THBD [[rs1042580]], together with three single F5 SNPs, was associated with CVD events. Among men, PROC [[rs1041296]], when combined with either ICAM1 [[rs5030341]] or F5 [[rs2269648]], was associated with total mortality. As a single variant, PROC [[rs1401296]], together with the F5 Leiden mutation, was associated with ischemic stroke events.{{PMID|17677000|OA=1
}}

{{PMID Auto
|PMID=24602049
|Title=Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves
}}

{{PMID Auto
|PMID=25225421
|Title=Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}