{{Rsnum
|rsid=10455872
|Gene=LPA
|Chromosome=6
|position=160589086
|Orientation=plus
|GMAF=0.03122
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LPA
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 86.2 | 12.3 | 1.5
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=20032323
|Title=Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
}}
[[rs10455872]], was associated with about 1.5-fold increased risk of [[Coronary Heart Disease]].
[http://www.marketwatch.com/story/celera-publishes-data-validating-an-increased-risk-of-coronary-heart-disease-in-carriers-of-two-lpa-gene-variants-2010-06-08?reflink=MW_news_stmp celera]

{{PMID Auto
|PMID=20160194
|Title=Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians
}}
{{PMID Auto
|PMID=20605575
|Title=Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus
}}

{{omim
|id=152200
|rsnum=10455872
}}

{{PMID Auto
|PMID=21900290
|Title=Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=22368281
|Title=Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: Importance of Lp(a).
|OA=1
}}

{{PMID Auto GWAS
|PMID=22331829
|Trait=None
|Title=Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
|RiskAllele=
|Pval=5E-15
|OR=6.8000
|ORtxt=None
}}

{{PMID|21127300|OA=1
}} Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.

{{PMID|21252144}} Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.

{{PMID|21283670|OA=1
}} Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

{{PMID|21305047|OA=1
}} Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey.

{{PMID|22560621}} Cost-effectiveness model of use of genetic testing as an aid in assessing the likely benefit of aspirin therapy for primary prevention of cardiovascular disease.

{{PMID Auto GWAS
  |PMID=23118302
  |Trait=Lipoprotein-associated phospholipase A2 activity change in response to statin therapy
  |Title=Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
  |RiskAllele=G
  |Pval=2E-16
  |OR=4.80
  |ORtxt=[0.82-2.78] percent increase
  }}

{{PMID Auto
|PMID=23735648
|Title=Validation and Quantification of Genetic Determinants of Lipoprotein-a Levels and Predictive Value for Angiographic Coronary Artery Disease
}}

{{PMID Auto
|PMID=23978127
|Title=Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention
|OA=1
}}

{{PMID Auto
|PMID=24161338
|Title=Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population
}}

{{PMID Auto GWAS
  |PMID=23388002
  |Trait=Aortic-valve calcification
  |Title=Genetic associations with valvular calcification and aortic stenosis.
  |RiskAllele=G
  |Pval=3E-11
  |OR=2.05
  |ORtxt=[1.66-2.53]
  |OA=1
}}

{{PMID Auto
|PMID=24622370
|Title=Lipoprotein(a) concentrations, isoform size, and risk of type 2 diabetes: a Mendelian randomisation study
}}

{{PMID Auto
|PMID=22898070
|Title=Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.
}}

{{PMID Auto
|PMID=23100282
|Title=Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
|OA=1
}}

{{PMID Auto
|PMID=23278389
|Title=Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(A) gene.
}}

{{PMID Auto
|PMID=23375930
|Title=Extreme lipoprotein(a) levels and improved cardiovascular risk prediction.
}}

{{PMID Auto
|PMID=24776095
|Title=LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography
}}

{{PMID Auto
|PMID=24903972
|Title=Genetic predisposition to calcific aortic stenosis and mitral annular calcification
}}

{{PMID Auto GWAS
  |PMID=24262325
  |Trait=Coronary artery disease or ischemic stroke
  |Title=Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
  |RiskAllele=
  |Pval=2E-12
  |OR=NR
  |ORtxt=NR
  }}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}