{{Rsnum
|rsid=1045644
|Gene=COCH
|Chromosome=14
|position=30885890
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.4665
|Gene_s=COCH,RPS4XP13
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 11.5 | 46.0 | 42.5
| HCB | 30.7 | 56.9 | 12.4
| JPT | 46.9 | 41.6 | 11.5
| YRI | 66.7 | 32.0 | 1.4
| ASW | 47.4 | 40.4 | 12.3
| CHB | 30.7 | 56.9 | 12.4
| CHD | 45.0 | 42.2 | 12.8
| GIH | 41.6 | 39.6 | 18.8
| LWK | 58.2 | 36.4 | 5.5
| MEX | 17.2 | 44.8 | 37.9
| MKK | 48.7 | 47.4 | 3.9
| TSI | 15.7 | 47.1 | 37.3
| HapMapRevision=28
}}{{Venter SNP
|rsid=1045644
|allele=G
|frequency=0.417
|uid=1103649023186
|type=heterozygous_SNP
|hugo=COCH
|ensembl gene=ENSG00000100473
|ensembl transcript=ENST00000216361
|sift=TOLERATED
|disease=Defects in COCH may contribute to Meniere disease (MIM:156000). Meniere disease is an autosomal dominant disorder characterized by hearing loss associated with episodic vertigo. Antibodies against COCH are found in 10% of Meniere patients.
}}

{{PMID|18520591|OA=1
}} Sequence variants in host cell factor C1 are associated with Meniere's disease.

{{GET Evidence
|gene=COCH
|aa_change=Thr352Ser
|aa_change_short=T352S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1045644
|overall_frequency_n=5479
|overall_frequency_d=10758
|overall_frequency=0.509295
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-2
|autoscore=2
|n_web_uneval=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}