{{Rsnum
|rsid=10468017
|Chromosome=15
|position=58386313
|Orientation=plus
|GMAF=0.2094
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=LOC102724766
|Gene_s=LOC102724766
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 42.9 | 52.7 | 4.5
| HCB | 67.7 | 27.8 | 4.5
| JPT | 58.6 | 36.0 | 5.4
| YRI | 80.3 | 18.3 | 1.4
| ASW | 75.0 | 19.6 | 5.4
| CHB | 67.7 | 27.8 | 4.5
| CHD | 73.8 | 23.4 | 2.8
| GIH | 63.4 | 30.7 | 5.9
| LWK | 83.5 | 15.6 | 0.9
| MEX | 70.7 | 27.6 | 1.7
| MKK | 67.9 | 28.8 | 3.2
| TSI | 58.4 | 35.6 | 5.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=T
|Pval=8E-23
|OR=0.10
|ORtxt=[0.06-0.14] SD increase
|OA=1
}}

T allele is associated with 1.76mg/dl increase in [[HDL cholesterol]] (good cholesterol). {{PMID|18193043}}

{{PharmGKB
|RSID=rs10468017
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 15q22.1; Reported Gene(s): LIPC; Risk Allele: rs10468017-T); (p-value= 8E-23).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740244
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
|OA=1
}}
{{PMID Auto
|PMID=21139980
|Title=Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration
|OA=1
}}

{{PMID Auto GWAS
|PMID=21386085
|Trait=None
|Title=A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
|RiskAllele=C
|Pval=6E-8
|OR=0.1600
|ORtxt=[0.10-0.22] unit increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=21665990
|Trait=None
|Title=Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|RiskAllele=
|Pval=3E-12
|OR=1.1900
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=22247473
|Title=Prospective Assessment of Genetic Effects on Progression to Different Stages of Age-related Macular Degeneration Using Multi-state Markov Models
|OA=1
}}

{{PMID Auto GWAS
|PMID=21943158
|Trait=None
|Title=Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
|RiskAllele=T
|Pval=3E-12
|OR=0.1040
|ORtxt=[0.075-0.133] mmol/l increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=22359512
|Trait=None
|Title=Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
|RiskAllele=
|Pval=7E-43
|OR=0
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=20385819
|Title=Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10468017
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24223199
|Title=Association of HDL-Related Loci with Age-Related Macular Degeneration and Plasma Lutein and Zeaxanthin: the Alienor Study
|OA=1
}}

{{PMID Auto
|PMID=22692312
|Title=[Mendelian randomization study of the relationship between high-density lipoprotein cholesterol and age-related macular degeneration].
}}

{{PMID Auto
|PMID=23348725
|Title=Association of LIPC and advanced age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=25010633
|Title=The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}