{{Rsnum
|rsid=1047286
|Gene=C3
|Chromosome=19
|position=6713251
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.08586
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=C3
}}[[rs1047286]] is a SNP in the complement component C3 gene.

A 2011 meta-analysis of seven studies concluded that, at least for Caucasians, the [[rs1047286]](C;T) and (T;T) genotypes had 1.27 (CI: 1.15 - 1.41) and 1.70 (CI: 1.27 - 2.11) times higher risk of [[ARMD]] than did (G;G) genotypes. {{PMID|21576320}}

{{omim
|desc=C3 POLYMORPHISM, HAV 4-1 PLUS/MINUS TYPE
|id=120700
|rsnum=1047286
|variant=0002
}}
{{ neighbor
| rsid = 2230199
| distance = 5125
}}
{{ neighbor
| rsid = 2230201
| distance = 29
}}

{{PMID Auto
|PMID=19399715
|Title=Impact of interacting functional variants in COMT on regional gray matter volume in human brain
}}

{{PMID Auto
|PMID=19234341
|Title=Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration
}}
{{PMID Auto
|PMID=19850835
|Title=The noncoding variant in complement factor H gene increases risk of exudative age-related macular degeneration in a Chinese population
}}

{{ClinVar
|rsid=1047286
|Reversed=1
|FwdREF=C
|FwdALT=T
|REF=G
|ALT=A
|RSPOS=6713262
|CHROM=19
|GMAF=0.0856
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050168000000170516110101
|GENEINFO=C3:718
|GENE_NAME=C3
|GENE_ID=718
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.6713262G>A
|CLNORIGIN=1
|CLNSIG=2
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9141; 0.08586
|CLNACC=RCV000018586.1
|CLNDBN=C3 POLYMORPHISM, HAV 4-1 PLUS/MINUS TYPE
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=120700.0002
|COMMON=1
|Disease=C3 POLYMORPHISM
}}

{{PMID Auto
|PMID=19828715
|Title=Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome.
}}

{{PMID Auto
|PMID=20157618
|Title=Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.
|OA=1
}}

{{PMID Auto
|PMID=20664795
|Title=R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population.
|OA=1
}}

{{PMID Auto
|PMID=22273503
|Title=Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population.
}}

{{GET Evidence
|gene=C3
|aa_change=Pro314Leu
|aa_change_short=P314L
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1047286
|overall_frequency_n=1566
|overall_frequency_d=10758
|overall_frequency=0.145566
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.159
|genetests_testable=Y
|nblosum100=7
|autoscore=2
|n_web_uneval=9
}}

{{PMID Auto
|PMID=23582991
|Title=Genetic Influences on the Outcome of Anti-Vascular Endothelial Growth Factor Treatment in Neovascular Age-related Macular Degeneration
}}

{{PMID Auto
|PMID=23068452
|Title=Common polymorphisms in the complement system and susceptiblity to bacterial meningitis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}