{{Rsnum
|rsid=1047781
|Gene=FUT2
|Chromosome=19
|position=48703374
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=T
|GMAF=0.101
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=FUT2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 33.3 | 53.3 | 13.3
| JPT | 29.5 | 63.6 | 6.8
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 33.3 | 53.3 | 13.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs1047781]], also known as Ile129Phe, is found on chromosome 19 in the alpha(1,2)-fucosyltransferase [[FUT2]] gene. The wild-type [[rs1047781]](A) encodes the 'Secretor' allele, while [[rs1047781]](T) encodes the 'nonsecretor' (se2 or sej) allele.

This basis for FUT2 nonsecretor status is found primarily in Japanese. In Caucasians, nonsecretor status is associated with the se1 allele of [[rs601338]], and [[rs1047781]] genotype shows almost no variation. In Japanese, the se1 allele is absent, but 15% of individuals are non-secretors based on being homozygous for [[rs1047781]](T;T).{{PMID|8621666}}

{{omim
|id=182100
|rsnum=1047781
|variant=0002
}}

{{PMID Auto GWAS
|PMID=22367966
|Trait=None
|Title=Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|RiskAllele=
|Pval=4E-36
|OR=70.2100
|ORtxt=None
}}

{{ClinVar
|rsid=1047781
|Reversed=0
|FwdREF=A
|FwdALT=T
|REF=A
|ALT=T
|RSPOS=49206631
|CHROM=19
|GMAF=0.1007
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050168000000150517130100
|GENEINFO=FUT2:2524
|GENE_NAME=FUT2
|GENE_ID=2524
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.49206631A>T
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.899; 0.101
|CLNACC=RCV000013811.1
|CLNDBN=SECRETOR/NONSECRETOR POLYMORPHISM, JAPANESE TYPE
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=182100.0002
|COMMON=1
|Disease=SECRETOR/NONSECRETOR POLYMORPHISM
}}

{{GET Evidence
|gene=FUT2
|aa_change=Ile140Phe
|aa_change_short=I140F
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1047781
|overall_frequency_n=10
|overall_frequency_d=10754
|overall_frequency=0.000929886
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.942
|nblosum100=2
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23300138
  |Trait=Tumor biomarkers
  |Title=A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
  |RiskAllele=T
  |Pval=6E-209
  |OR=.24
  |ORtxt=[0.21-0.26] ng/ml increase
  }}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}