{{Rsnum
|rsid=10483639
|Gene=GCH1
|Chromosome=14
|position=54839739
|Orientation=plus
|GMAF=0.2948
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 5.3 | 39.8 | 54.9
| HCB | 12.4 | 46.0 | 41.6
| JPT | 16.8 | 45.1 | 38.1
| YRI | 13.6 | 51.0 | 35.4
| ASW | 10.5 | 52.6 | 36.8
| CHB | 12.4 | 46.0 | 41.6
| CHD | 11.9 | 43.1 | 45.0
| GIH | 2.0 | 25.7 | 72.3
| LWK | 5.5 | 43.6 | 50.9
| MEX | 5.2 | 53.4 | 41.4
| MKK | 11.5 | 34.6 | 53.8
| TSI | 2.0 | 22.5 | 75.5
| HapMapRevision=28
}}Do genetic predictors of pain sensitivity associate with persistent widespread pain? C allele associated with higher pain tolerance.{{PMID|19775452|OA=1
}}

[[GCH1]] haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Part of a haplotype, [[rs10483639]](C)-[[rs3783641]](A)-[[rs8007267]](T), associated with lower levels of [[tetrahydrobiopterin]].{{PMID|18598896|OA=1
}}

{{PMID Auto
|PMID=17343757
|Title=Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.
|OA=1
}}

{{PMID Auto
|PMID=17363416
|Title=Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.
}}

{{PMID Auto
|PMID=19751821
|Title=Oxidative risk for atherothrombotic cardiovascular disease.
|OA=1
}}

{{PMID Auto
|PMID=20633294
|Title=Different SNP combinations in the GCH1 gene and use of labor analgesia.
|OA=1
}}

{{PMID Auto
|PMID=23059057
|Title=A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study
|OA=1
}}

{{PMID Auto
|PMID=25218601
|Title=Epistasis Between Polymorphisms in COMT, ESR1, and GCH1 Influences COMT Enzyme Activity and Pain
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}