{{Rsnum
|rsid=10484554
|Chromosome=6
|position=31306778
|Orientation=plus
|GMAF=0.1074
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 75.7 | 21.6 | 2.7
| HCB | 79.4 | 19.8 | 0.8
| JPT | 94.5 | 5.5 | 0.0
| YRI | 93.8 | 6.2 | 0.0
| ASW | 80.7 | 19.3 | 0.0
| CHB | 79.4 | 19.8 | 0.8
| CHD | 80.2 | 18.9 | 0.9
| GIH | 49.0 | 42.0 | 9.0
| LWK | 63.9 | 35.2 | 0.9
| MEX | 78.2 | 21.8 | 0.0
| MKK | 63.9 | 32.9 | 3.2
| TSI | 63.4 | 31.7 | 5.0
| HapMapRevision=28
}}

{{PMID|18369459|OA=1
}} [[rs10484554]] was the most highly significant SNP associated with risk for [[psoriasis]] in a large US/UK study.

{{PMID|24270849|OA=1
}} [[rs10484554]] was found to be associated with [[psoriasis]] based on a study by the eMERGE network in which electronic medical records were searched to find what clinical associations were associated with selected SNPs.
{{ neighbor
| rsid = 9264942
| distance = 175
}}
{{PMID Auto GWAS
|PMID=19115949
|Trait=AIDS progression
|Title=Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).
|RiskAllele=T
|Pval=6E-8
|OR=NR
|ORtxt=NR
}}
{{PharmGKB
|RSID=rs10484554
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19115949; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).. (Initial Sample Size: 275 HIV positive patients, 1,438 controls; Replication Sample Size: 626 patients); (Region: 6p21.33; Reported Gene(s): HLA-C; Risk Allele: rs10484554-T); (p-value= 0.00000006).This variant is associated with AIDS progression.
|Drugs=
|Drug Classes=
|Diseases=Acquired Immunodeficiency Syndrome
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740093
}}

{{omim
|desc=HLA COMPLEX P5 GENE; HCP5
|id=604676
|rsnum=10484554
}}

{{PMID Auto GWAS
|PMID=20953190
|Trait=None
|Title=A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
|RiskAllele=
|Pval=0
|OR=4.6600
|ORtxt=[4.23-5.13]
|OA=1
}}

{{PMID|19107206|OA=1
}} Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.

{{PMID|19182814|OA=1
}} New insights into the pathogenesis and genetics of psoriatic arthritis.

{{PMID|19569043|OA=1
}} Genome-wide association studies and the genetic dissection of complex traits.

{{PMID|21221856|OA=1
}} The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery.

{{PMID|21253569|OA=1
}} Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?

{{PMID|21304891|OA=1
}} A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.

{{PMID|22474614|OA=1
}} Host Genes Important to HIV Replication and Evolution.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10484554
|overall_frequency_n=12
|overall_frequency_d=114
|overall_frequency=0.105263
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto
|PMID=24566686
|Title=Human leukocyte antigen (HLA)-C polymorphisms are associated with a decreased risk of rheumatoid arthritis
}}

{{PMID Auto
|PMID=22931917
|Title=Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}