{{Rsnum
|rsid=10485057
|Gene=OPRM1
|Chromosome=6
|position=154092120
|Orientation=plus
|GMAF=0.09917
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=OPRM1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 76.9 | 21.5 | 1.5
| HCB | 91.1 | 8.9 | 0.0
| JPT | 95.5 | 4.5 | 0.0
| YRI | 77.8 | 19.0 | 3.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 91.1 | 8.9 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs10485057]] is a SNP in the opioid receptor, mu 1 [[OPRM1]] gene.

A study of 688 Caucasian smokers (and non-smoking controls) indicated that the rare [[rs10485057]](G) allele was associated with higher likelihood of smoking initiation and [[nicotine dependence]]. {{PMID|16887046|OA=1
}}

{{PMID Auto
|PMID=24766998
|Title=Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}