{{Rsnum
|rsid=10486567
|Gene=JAZF1
|Chromosome=7
|position=27936944
|Orientation=plus
|GMAF=0.4541
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=JAZF1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.1 | 35.4 | 57.5
| HCB | 77.2 | 19.9 | 2.9
| JPT | 80.5 | 15.9 | 3.5
| YRI | 8.2 | 46.6 | 45.2
| ASW | 8.8 | 42.1 | 49.1
| CHB | 77.2 | 19.9 | 2.9
| CHD | 79.4 | 20.6 | 0.0
| GIH | 9.9 | 47.5 | 42.6
| LWK | 16.5 | 44.0 | 39.4
| MEX | 13.8 | 53.4 | 32.8
| MKK | 17.4 | 44.5 | 38.1
| TSI | 3.9 | 35.3 | 60.8
| HapMapRevision=28
}}[http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.91.html nature] identifies [[rs10486567]] [[rs10993994]] [[rs10896449]] in [[prostate cancer]]

{{GWAS Summary
|SNP=rs10486567
|PubMedID=18264096
|Condition=Prostate cancer (aggressive)
|Gene=JAZF1
|Risk Allele=G
|pValue=2.00E-006
|OR=1.12
|95CI=1.02-1.25
}}

{{omim
|desc=JUXTAPOSED WITH ANOTHER ZINC FINGER GENE 1; JAZF1
|id=606246
|rsnum=10486567
}}

{{PharmGKB
|RSID=rs10486567
|Name_s=
|Gene_s=JAZF1
|Feature=
|Evidence=PubMed ID:18264096; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple loci identified in a genome-wide association study of prostate cancer (Initial Sample Size: 1,172 cases, 1,157 controls; Replication Sample Size: 3,941 cases, 3,964 controls; Risk Allele: rs10486567-G).
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356741
}}

{{PMID Auto
|PMID=20406958
|Title=Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2
|OA=1
}}
{{PMID Auto
|PMID=20460480
|Title=Susceptibility loci associated with prostate cancer progression and mortality
|OA=1
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=18974127
|Title=Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19104501
|Title=Prostate cancer genomics: towards a new understanding.
|OA=1
}}

{{PMID Auto
|PMID=19318432
|Title=Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=19366831
|Title=Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19838195
|Title=A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=19998368
|Title=HNF1B and JAZF1 genes, diabetes, and prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20450899
|Title=Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.
}}

{{PMID Auto
|PMID=20569440
|Title=Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=21071540
|Title=Validation of genome-wide prostate cancer associations in men of African descent.
|OA=1
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{PMID Auto
|PMID=21538423
|Title=Early onset prostate cancer has a significant genetic component.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10486567
|overall_frequency_n=42
|overall_frequency_d=128
|overall_frequency=0.328125
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24411283
|Title=Prostate Cancer (PCa) Risk Variants and Risk of Fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
}}

{{PMID Auto
|PMID=24497837
|Title=Comprehensive functional annotation of 77 prostate cancer risk Loci
|OA=1
}}

{{PMID Auto
|PMID=24801046
|Title=Gene-environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}