{{Rsnum
|rsid=104894503
|Chromosome=15
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=TPM1
|position=63060899
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=TPM1
}}{{omim
|id=191010
|rsnum=104894503
|variant=0002
}}{{ClinVar
|rsid=104894503
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=63353098
|CHROM=15
|dbSNPBuildID=132
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=TPM1:7168
|GENE_NAME=TPM1
|GENE_ID=7168
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000015.9:g.63353098G>A
|CLNSRC=Leiden Muscular Dystrophy pages (TPM1); OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=TPM1_00009; 191010.0002
|CLNSIG=5
|CLNCUI=C1861863
|CLNDBN=Familial hypertrophic cardiomyopathy 3; Primary familial hypertrophic cardiomyopathy; Sudden cardiac death
|Disease=Familial hypertrophic cardiomyopathy 3; Primary familial hypertrophic cardiomyopathy; Sudden cardiac death
|CLNACC=RCV000013272.21; RCV000030624.1; RCV000036340.1
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM; GeneReviews:MedGen:SNOMED_CT; MedGen:SNOMED_CT
|CLNDSDBID=NBK1768:C1861863:115196; NBK1768:C0949658:83978005; C0085298:95281009
}}{{PMID Auto
|PMID=7787263
|Title=The molecular genetics of cardiovascular disease.
}}

{{PMID Auto
|PMID=9742053
|Title=Familial hypertrophic cardiomyopathy: from mutations to functional defects.
}}

{{PMID Auto
|PMID=9822100
|Title=The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.
}}

{{PMID Auto
|PMID=10444398
|Title=Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy.
}}

{{PMID Auto
|PMID=10900175
|Title=Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay.
}}

{{PMID Auto
|PMID=15479242
|Title=Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human alpha-tropomyosin.
}}

{{PMID Auto
|PMID=7729014
|Title=A de novo mutation in alpha-tropomyosin that causes hypertrophic cardiomyopathy.
}}

{{PMID Auto
|PMID=7898523
|Title=Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.
}}

{{PMID Auto
|PMID=8205619
|Title=Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.
}}

{{PMID Auto
|PMID=8523464
|Title=Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy.
}}

{{PMID Auto
|PMID=8774330
|Title=Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene.
|OA=1
}}

{{PMID Auto
|PMID=9060904
|Title=Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene.
}}

{{PMID Auto
|PMID=9440709
|Title=A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity.
}}

{{PMID Auto
|PMID=11968089
|Title=Low-density DNA microarrays are versatile tools to screen for known mutations in hypertrophic cardiomyopathy.
}}

{{PMID Auto
|PMID=14734051
|Title=Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene.
}}

{{PMID Auto
|PMID=16014439
|Title=Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene.
}}

{{PMID Auto
|PMID=16504640
|Title=Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beta-myosin heavy chain, alpha-tropomyosin, and myosin-binding protein C genes.
}}

{{PMID Auto
|PMID=18403758
|Title=Shared genetic causes of cardiac hypertrophy in children and adults.
|OA=1
}}

{{PMID Auto
|PMID=19035361
|Title=Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives.
}}