{{Rsnum
|rsid=104894574
|Chromosome=17
|Orientation=minus
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene=HCRT
|position=42184503
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=HCRT
}}[[rs104894574]], also known as Leu16Arg or L16R, is a SNP in the hypocretin (orexin) neuropeptide precursor [[HCRT]] gene.

In a heterozygous individual, this SNP has been associated with a severe form of [[narcolepsy]].{{PMID|10973318}}

{{omim
|id=602358
|rsnum=104894574
|variant=0001
}}{{ClinVar
|rsid=104894574
|Reversed=1
|FwdREF=T
|FwdALT=G
|REF=A
|ALT=C
|RSPOS=40336521
|CHROM=17
|dbSNPBuildID=132
|SSR=0
|SAO=1
|VP=0x050060000000000002110100
|GENEINFO=HCRT:3060
|GENE_NAME=HCRT
|GENE_ID=3060
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000017.10:g.40336521A>C
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=602358.0001
|CLNSIG=5
|CLNCUI=C1834372
|CLNDBN=Narcolepsy
|Disease=Narcolepsy
|CLNACC=RCV000007726.1
|Tags=RV;PM;OTHERKG;LSD;OM
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C1834372:161400:2073
}}