{{Rsnum
|rsid=1048990
|Gene=PSMA6
|Chromosome=14
|position=35292469
|Orientation=plus
|GMAF=0.1951
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PSMA6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 78.5 | 20.0 | 1.5
| HCB | 37.8 | 48.9 | 13.3
| JPT | 34.1 | 50.0 | 15.9
| YRI | 96.8 | 3.2 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 37.8 | 48.9 | 13.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs1048990]], also known as the exon-1 -8C/G SNP in the [[PSMA6]] gene, has been reported in a large study of Japanese patients to be associated with increased risk for myocardial infarction ([[heart disease]]). {{PMID|16845397}}

The risk allele (oriented to the dbSNP entry) is (G). The odds ratio (based on an additive model) is 1.48 (CI 1.23-1.77, p = 1.2 x 10e-5). {{PMID|16845397}}

{{PMID|18231128}} given the rarity of this variant in Caucasians, the attributable risk of rs1048990 for MI is unlikely to be great in western populations

{{PMID|19272601}} Various ways of calculating the association between [[rs1048990]] and myocardial infarction all led to odds ratios of around 1.2 - 1.5 in a case-control association study on a cohort of 1,884 MI patients and 2,643 unrelated controls from the Chinese population.

{{PMID Auto
|PMID=19182073
|Title=Genetic variation in the lymphotoxin-alpha pathway and the risk of ischemic stroke in European populations.
}}

{{omim
|id=602855
|desc=PROTEASOME SUBUNIT, ALPHA-TYPE, 6; PSMA6
|rsnum=1048990
}}
{{PMID Auto
|PMID=19624571
|Title=Haplotypes Encompassing the KIAA0391 and PSMA6 Gene Cluster Confer a Genetic Link for Myocardial Infarction and Coronary Artery Disease
}}

{{omim
|id=602855
|rsnum=1048990
|variant=0001
}}

{{PMID Auto
|PMID=22310064
|Title=Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: a pathological study of 1503 consecutive autopsy cases
}}

{{PMID Auto
|PMID=17767904
|Title=Genetic and genomic insights into the molecular basis of atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19503741
|Title=Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=19753309
|Title=SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=20157514
|Title=Positive association of common variants in CD36 with neovascular age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=23111455
|Title=Quantitative assessment of the influence of PSMA6 variant (rs1048990) on coronary artery disease risk
}}

{{PMID Auto
|PMID=24455213
|Title=Association of obesity with proteasomal gene polymorphisms in children
|OA=1
}}

{{PMID Auto
|PMID=22882272
|Title=Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke.
|OA=1
}}

{{PMID Auto
|PMID=24875235
|Title=Juvenile Idiopathic Arthritis Subtype- and Sex-specific Associations with Genetic Variants in the PSMA6/PSMC6/PSMA3 Gene Cluster
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}