{{Rsnum
|rsid=10490923
|Gene=ARMS2
|Chromosome=10
|position=124214251
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.07254
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 24.6 | 75.4
| HCB | 0.0 | 4.4 | 95.6
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 6.3 | 93.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 4.4 | 95.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19268887
|Title=ARMS2 (LOC387715) Variants in Japanese Patients with Exudative Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy.
}}

{{PMID Auto
|PMID=19933179
|Title=Inverse association of female hormone replacement therapy and oral contraceptive use with age-related macular degeneration and interactions with ARMS2 polymorphisms
|OA=1
}}

{{PMID Auto
|PMID=16080115
|Title=Susceptibility genes for age-related maculopathy on chromosome 10q26.
|OA=1
}}

{{PMID Auto
|PMID=16642439
|Title=Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=17325155
|Title=The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples.
|OA=1
}}

{{PMID Auto
|PMID=18162041
|Title=Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.
|OA=1
}}

{{PMID Auto
|PMID=18688167
|Title=Polymorphisms in the LOC387715/ARMS2 putative gene and the risk for Alzheimer's disease.
}}

{{PMID Auto
|PMID=19259132
|Title=Multilocus analysis of age-related macular degeneration.
|OA=1
}}

{{GET Evidence
|gene=ARMS2
|aa_change=Arg3His
|aa_change_short=R3H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10490923
|overall_frequency_n=991
|overall_frequency_d=10284
|overall_frequency=0.0963633
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=1
|autoscore=2
|n_web_uneval=9
}}

{{PMID Auto
|PMID=23534868
|Title=CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) Gene Polymorphisms are Associated with AMD Risk in Spanish Patients
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}