{{Rsnum
|rsid=1049174
|Gene=KLRK1
|Chromosome=12
|position=10372766
|Orientation=minus
|GMAF=0.4348
|Gene_s=KLRC4-KLRK1,KLRK1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 6.2 | 42.2 | 51.6
| HCB | 22.2 | 33.3 | 44.4
| JPT | 18.2 | 34.1 | 47.7
| YRI | 40.3 | 51.6 | 8.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.2 | 33.3 | 44.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
High- and low-natural killer (NK) activity levels have been associated with haplotypes of the [[KLRK1]] gene defined by SNP [[rs1049174]]. The high NK (HNK) haplotype appears to have a protective effect (i.e. a reduced risk) for [[colorectal cancer]] based on a study of 379 Japanese patients.{{PMID|18174257}}

Note: HNK is reported to be associated with the [[rs1049174]](G) allele, and LNK with the (C) allele,  in at least two publications [PMID 16397273, PMID 18174257]. However, the orientation relative to dbSNP should be considered ambiguous until confirmed.

[[rs1049174]] is also reported to be in complete (100%) linkage with four other SNPs, which could therefore equally define the HNK/LNK haplotype; they are:
* [[rs2617160]]: reported as T>HNK, C>LNK, but this disagrees with dbSNP
* [[rs2617170]]: reported as A>HNK, T>LNK, but this disagrees with dbSNP; maybe rs2617160 and 2617170 were swapped in manuscript accidentally (?)
* [[rs2617171]]: reported as G>HNK, C>LNK
* [[rs1982526]]: reported as G>HNK, C>LNK